ArticleMolecular and cellular biology1994
Structure and function of ribosomal protein S4 genes on the human and mouse sex chromosomes.
Article in Molecular and cellular biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 88 citations in OpenAlex.
- Review
- A Novel Regulatory Role for RPS4Y1 in Inflammatory and Fibrotic Processes.International journal of molecular sciences · 2025Article
- Sex-specific regulatory architecture of pancreatic islets from subjects with and without type 2 diabetes.The EMBO journal · 2024Article
- Single cell regulatory architecture of human pancreatic islets suggests sex differences in β cell function and the pathogenesis of type 2 diabetes.Research square · 2024Article
- Single cell regulatory architecture of human pancreatic islets suggests sex differences in β cell function and the pathogenesis of type 2 diabetes.bioRxiv : the preprint server for biology · 2024Article
- High-throughput mRNA sequencing of human placenta shows sex differences across gestation.Placenta · 2024Article
- Genome-Wide Identification of Reference Genes for Reverse-Transcription Quantitative PCR in Goat Rumen.Animals : an open access journal from MDPI · 2021Article
- Development of a Specific Monoclonal Antibody to Detect Male Cells Expressing the RPS4Y1 Protein.International journal of molecular sciences · 2021Article
- RPS4Y1 Promotes High Glucose-Induced Endothelial Cell Apoptosis and Inflammation by Activation of the p38 MAPK Signaling.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Novel insights into non-HLA alloimmunity in kidney transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2020Review
- Does functional specialization of ribosomes really exist?RNA (New York, N.Y.) · 2019Review
- Sex influences DNA methylation and gene expression in human skeletal muscle myoblasts and myotubes.Stem cell research & therapy · 2019Article
- Overexpression of the X-linked ribosomal protein S4 predicts poor prognosis in patients with intrahepatic cholangiocarcinoma.Oncology letters · 2017Article
- Cyclic avian mass mortality in the northeastern United States is associated with a novel orthomyxovirus.Journal of virology · 2015Article
- The human RPS4 paralogue on Yq11.223 encodes a structurally conserved ribosomal protein and is preferentially expressed during spermatogenesis.BMC molecular biology · 2010Article
- RPS4Y gene family evolution in primates.BMC evolutionary biology · 2008Article
- SAGETTARIUS: a program to reduce the number of tags mapped to multiple transcripts and to plan SAGE sequencing stages.Nucleic acids research · 2007Article
- The architecture of mammalian ribosomal protein promoters.BMC evolutionary biology · 2005Article
- Targeted disruption of the ribosomal protein S19 gene is lethal prior to implantation.Molecular and cellular biology · 2004Article
- Functional second genes generated by retrotransposition of the X-linked ribosomal protein genes.Nucleic acids research · 2002Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human sex-linked genes RPS4X and RPS4Y encode distinct isoforms of ribosomal protein S4. Insufficient expression of S4 may play a role in the development of Turner syndrome, the complex human phenotype associated with monosomy X. In mice, the S4 protein is encoded by an X-linked gene, Rps4, and is identical to human S4X; there is no mouse Y homolog. We report here the organization of the human RPS4X and RPS4Y and mouse Rps4 genes. Each gene comprises seven exons; the positions of introns are conserved. The 5' flanking sequences of human RPS4X and mouse Rps4 are very similar, while RPS4Y diverges shortly upstream of the transcription start site. In chickens, S4 is encoded by a single gene that is not sex linked. The chicken protein differs from human S4X by four amino acid substitutions, all within a region encoded by a single exon. Three of the four substitutions are also present in human S4Y, suggesting that the chicken S4 gene may have arisen by recombination between S4X- and S4Y-like sequences. Using isoform-specific antisera, we determined that human S4X and S4Y are both present in translationally active ribosomes. S4Y is about 10 to 15% as abundant as S4X in ribosomes from normal male placental tissue and 46,XY cultured cells. In 49,XYYYY cells, S4Y is about half as abundant as S4X. In 49,XXXXY cells, S4Y is barely detectable. These results bear on the hypothesized role of S4 deficiency in Turner syndrome.
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