ArticleJournal of virology1994
Murine retrovirus-induced depletion of T cells is mediated through activation-induced death by apoptosis.
Article in Journal of virology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- MoMuLV-ts-1: A Unique Mouse Model of Retrovirus-Induced Lymphoma Transmitted by Breast Milk.Advances in virology · 2011Article
- Expression of murine leukemia virus envelope protein is sufficient for the induction of apoptosis.Journal of virology · 2008Article
- Induction of endoplasmic reticulum stress in thymic lymphocytes by the envelope precursor polyprotein of a murine leukemia virus during the preleukemic period.Journal of virology · 2007Article
- Retrovirus-induced oxidative stress with neuroimmunodegeneration is suppressed by antioxidant treatment with a refined monosodium alpha-luminol (Galavit).Journal of virology · 2006Article
- Astrocytes survive chronic infection and cytopathic effects of the ts1 mutant of the retrovirus Moloney murine leukemia virus by upregulation of antioxidant defenses.Journal of virology · 2006Article
- Cell-free human T-cell leukemia virus type 1 binds to, and efficiently enters mouse cells.Japanese journal of cancer research : Gann · 2002Article
- Essential roles for CD8+ T cells and gamma interferon in protection of mice against retrovirus-induced immunosuppression.Journal of virology · 2002Article
- Mink cell focus-forming murine leukemia virus killing of mink cells involves apoptosis and superinfection.Journal of virology · 2001Article
- Studies on the pathology, especially brain lesions, induced by R7, a spontaneous mutant of Moloney murine sarcoma virus 124.The American journal of pathology · 1998Article
- Immunodepression induced by Trypanosoma cruzi and mouse hepatitis virus type 3 is associated with thymus apoptosis.Clinical and diagnostic laboratory immunology · 1998Article
- Induction of T-cell apoptosis by human herpesvirus 6.Journal of virology · 1997Article
- Apoptosis and T-cell depletion during feline infectious peritonitis.Journal of virology · 1996Article
- Thymus involution induced by mouse hepatitis virus A59 in BALB/c mice.Journal of virology · 1995Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
ts1, a mutant of Moloney murine leukemia virus, causes neurologic disorders and acute immunodeficiency associated with the destruction of thymocytes and helper T cells. In this study, we examined whether apoptosis was involved in ts1-induced killings of T cells. Neonatal mice were inoculated with ts1, and 20 to 23 days postinoculation, when cytopathic effects on T cells normally appear, thymocytes and splenic lymphocytes were isolated and examined. Our results showed that several features of apoptosis were present in ts1-infected thymocytes and splenic lymphocytes. Apoptotic fragmented DNA, condensation of the chromatin, and enhanced cell death after stimulation with mitogens which was preventable with protein synthesis inhibitors, all of which are common features of apoptotic cell death, were observed in ts1-infected cells. Several other viruses, including human immunodeficiency virus, have been shown to cause apoptotic death of T cells. Here we show for the first time that a murine retrovirus which also induces immunodeficiency can cause apoptotic T-cell death. Future studies with this murine retrovirus may provide important results to help us better understand the mechanisms of retrovirus-induced apoptosis of T cells.
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Registered trials
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