ArticleGenetics1994
Fine structure mapping and deletion analysis of the murine piebald locus.
Article in Genetics, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 37 citations in OpenAlex.
- Article
- Molecular and functional mapping of the piebald deletion complex on mouse chromosome 14.Genetics · 2001Article
- Expression and functional analysis of Uch-L3 during mouse development.Molecular and cellular biology · 2000Article
- Sympathoadrenal hyperplasia causes renal malformations in Ret(MEN2B)-transgenic mice.The American journal of pathology · 1999Article
- A new inbred strain JF1 established from Japanese fancy mouse carrying the classic piebald allele.Mammalian genome : official journal of the International Mammalian Genome Society · 1998Article
- Molecular characterization of four induced alleles at the Ednrb locus.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Physical mapping of the endothelin receptor type B to bovine chromosome 12.Mammalian genome : official journal of the International Mammalian Genome Society · 1997Article
- Complementation mapping of skeletal and central nervous system abnormalities in mice of the piebald deletion complex.Genetics · 1996Article
- Chromosome 13q deletion with Waardenburg syndrome: further evidence for a gene involved in neural crest function on 13q.Journal of medical genetics · 1995Article
- Piebald lethal (sl) acts early to disrupt the development of neural crest-derived melanocytes.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
piebald (s) is a recessive mutation that affects the development of two cell types of neural crest origin: the melanocytes, responsible for pigment synthesis in the skin, and enteric ganglia, which innervate the lower bowel. As a result, mice carrying piebald mutations exhibit white spotting in the coat and aganglionic megacolon. Previously the gene had been localized to the distal half of mouse chromosome 14. To determine its precise location relative to molecular markers, an intersubspecific backcross was generated. Two anchor loci of chromosome 14, slaty and hypogonadal, in addition to simple sequence length repeat markers, were used to localize s to a 2-cM interval defined by the markers D14Mit38 and D14Mit42. The molecular markers were also used to characterize nine induced s alleles. Three of these mutations exhibited no deletions or rearrangements of the flanking markers, whereas the other six had two or more of these markers deleted. The extent of the deletions was found to be consistent with the severity of the homozygous phenotype. The location of deletion breakpoints in the induced alleles, coupled with the recombination breakpoints in the backcross progeny, provide useful molecular landmarks to define the location of the piebald gene.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.