ArticleThe EMBO journal1994
Transcriptional activation through the tetrameric complex formation of E4TF1 subunits.
Article in The EMBO journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 50 citations in OpenAlex.
- Article
- Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner.Cancer cell · 2018Article
- Regulation of mutant TERT by BRAF V600E/MAP kinase pathway through FOS/GABP in human cancer.Nature communications · 2018Article
- Ets transcription factor GABP controls T cell homeostasis and immunity.Nature communications · 2017Article
- Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers.Genes & development · 2015Article
- Cancer. The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer.Science (New York, N.Y.) · 2015Article
- The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense.Cell reports · 2013Article
- GABPbeta2 is dispensible for normal lymphocyte development but moderately affects B cell responses.The Journal of biological chemistry · 2008Article
- Targeting the GA binding protein beta1L isoform does not perturb lymphocyte development and function.Molecular and cellular biology · 2008Article
- Human Spt6 stimulates transcription elongation by RNA polymerase II in vitro.Molecular and cellular biology · 2004Article
- Phosphorylation-elicited quaternary changes of GA binding protein in transcriptional activation.Molecular and cellular biology · 2003Article
- Regulation of E2F1-dependent gene transcription and apoptosis by the ETS-related transcription factor GABPgamma1.Molecular and cellular biology · 2002Article
- Review
- Synergistic action of GA-binding protein and glucocorticoid receptor in transcription from the mouse mammary tumor virus promoter.Journal of virology · 2000Article
- The Cdc2 protein kinase controls Cdc10/Sct1 complex formation.Molecular biology of the cell · 1997Article
- Functional domains of transcription factor hGABP beta1/E4TF1-53 required for nuclear localization and transcription activation.Nucleic acids research · 1996Article
- Regional mapping of two subunits of transcription factor E4TF1 to human chromosome.Japanese journal of cancer research : Gann · 1995Article
- Four structurally distinct, non-DNA-binding subunits of human nuclear respiratory factor 2 share a conserved transcriptional activation domain.Molecular and cellular biology · 1995Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcription factor E4TF1 is composed of two types of subunit, an ets-related DNA binding protein, E4TF1-60, and its associated proteins with four tandemly repeated Notch-ankyrin motifs, E4TF1-53 and E4TF1-47. To determine the functional domains, we constructed various mutants of the subunits. E4TF1-60 bound to DNA as a monomer. The ets domain and its N-terminal flanking region were necessary to recognize the specific DNA sequence. The 48 amino acids at the E4TF1-60 C-terminus were required for interaction with the other type of subunit. E4TF1-53 and E4TF1-47 share the N-terminal 332 amino acids but differ at the C-termini. They interacted with E4TF1-60 through the N-terminal flanking region to form a heterodimer. E4TF1-53 dimerized with itself, whereas E4TF1-47 did not. The C-terminal region specific for E4TF1-53 was required for the dimerization. Therefore, heterodimers composed of E4TF1-53 and E4TF1-60 were further dimerized, resulting in the formation of a tetrameric complex, which stimulated transcription in vitro. Heterodimers of E4TF1-47 and E4TF1-60 weakly stimulated transcription in vitro. The results indicated that the tetrameric complex formation of E4TF1 subunits was necessary to activate transcription efficiently in vitro.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.