ArticleThe EMBO journal1994
STF-IL-4: a novel IL-4-induced signal transducing factor.
Article in The EMBO journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 181 citations in OpenAlex.
- High-throughput identification of Toxoplasma gondii effector proteins that target host cell transcription.Cell host & microbe · 2023Article
- IL-4 and IL-13 Receptor Signaling From 4PS to Insulin Receptor Substrate 2: There and Back Again, a Historical View.Frontiers in immunology · 2018Review
- Anti-inflammatory cytokine interleukin-4 inhibits inducible nitric oxide synthase gene expression in the mouse macrophage cell line RAW264.7 through the repression of octamer-dependent transcription.Mediators of inflammation · 2013Article
- Molecular characterization of the porcine STAT4 and STAT6 genes.Molecular biology reports · 2012Article
- The transcriptional regulator NFIL3 controls IgE production.Transactions of the American Clinical and Climatological Association · 2010Review
- An atopy-associated polymorphism in the ectodomain of the IL-4R(alpha) chain (V50) regulates the persistence of STAT6 phosphorylation.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Inteferons pen the JAK-STAT pathway.Seminars in cell & developmental biology · 2008Review
- Unphosphorylated STAT6 contributes to constitutive cyclooxygenase-2 expression in human non-small cell lung cancer.Oncogene · 2007Article
- Histamine affects STAT6 phosphorylation via its effects on IL-4 secretion: role of H1 receptors in the regulation of IL-4 production.International immunopharmacology · 2007Article
- The key regulators of adult T helper cell responses, STAT6 and T-bet, are established in early life in mice.European journal of immunology · 2006Article
- Hyper immunoglobulin E response in mice with monoclonal populations of B and T lymphocytes.The Journal of experimental medicine · 2001Article
- The biology of Stat4 and Stat6.Oncogene · 2000Review
- Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4.The Journal of experimental medicine · 1999Article
- Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: specific regulation of iepsilon transcription and immunoglobulin E switching.Molecular and cellular biology · 1999Article
- STAT signaling in the pathogenesis and treatment of cancer.Molecular medicine (Cambridge, Mass.) · 1999Review
- Stat proteins control lymphocyte proliferation by regulating p27Kip1 expression.Molecular and cellular biology · 1998Article
- Regulation of interleukin 4-mediated signaling by naturally occurring dominant negative and attenuated forms of human Stat6.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Comparison of the transactivation domains of Stat5 and Stat6 in lymphoid cells and mammary epithelial cells.Molecular and cellular biology · 1997Article
- Cytokine transcriptional events during helper T cell subset differentiation.The Journal of experimental medicine · 1996Article
- Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene.Nature · 1996Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The mechanism by which interleukin-4 (IL-4) regulates the expression of particular genes is unknown. We have determined that IL-4 induces a DNA binding factor (termed STF-IL-4) which has a strong affinity for an IFN-gamma activation site (GAS). Interestingly, STF-IL-4 also binds to the IL-4 responsive promoter for the Ig heavy chain germline epsilon transcript. The IL-4 dependent activation of STF-IL-4 is rapid, does not require protein synthesis and results in the sequential appearance of binding activity first in the cytoplasm and then later in the nucleus. Activation of STF-IL-4 is sensitive to tyrosine kinase inhibitors and the active factor is tyrosine phosphorylated. This pattern of activation is similar to the activation of interferon-induced transcription factors. STF-IL-4 appears to be a new member of a growing family of cytokine-induced transcriptional regulators.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.