ArticleThe EMBO journal1994
Agonist-specific coupling of a cloned Drosophila octopamine/tyramine receptor to multiple second messenger systems.
Article in The EMBO journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it, 249 citations in OpenAlex.
- Neuroendocrinal and molecular basis of flight performance in locusts.Cellular and molecular life sciences : CMLS · 2022Pooled it
- Hunger recruits a parallel circuit encoding alcohol reward.Current biology : CB · 2026Article
- Molecular evolution of octopamine receptors in Drosophila.G3 (Bethesda, Md.) · 2026Article
- Octopamine receptors inFrontiers in molecular neuroscience · 2026Article
- Molecular evolution of octopamine receptors inbioRxiv : the preprint server for biology · 2025Article
- Hunger Recruits a Parallel Circuit Encoding Alcohol Reward.bioRxiv : the preprint server for biology · 2025Article
- GPCR signaling gates astrocyte responsiveness to neurotransmitters and control of neuronal activity.Science (New York, N.Y.) · 2025Article
- Compensatory enhancement of input maintains aversive dopaminergic reinforcement in hungry Drosophila.Neuron · 2024Article
- Regulation and modulation of biogenic amine neurotransmission inFrontiers in physiology · 2023Review
- She's got nerve: roles of octopamine in insect female reproduction.Journal of neurogenetics · 2021Review
- Neurofibromin regulates metabolic rate via neuronal mechanisms in Drosophila.Nature communications · 2021Article
- Review
- Developmental loss of neurofibromin across distributed neuronal circuits drives excessive grooming in Drosophila.PLoS genetics · 2020Article
- Characterization of an A-Type Muscarinic Acetylcholine Receptor and Its Possible Non-neuronal Role in the Oriental Armyworm,Frontiers in physiology · 2020Article
- Ligand-Induced Conformational Dynamics of A Tyramine Receptor from Sitophilus oryzae.Scientific reports · 2019Article
- Tyramine action on motoneuron excitability and adaptable tyramine/octopamine ratios adjustProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Octopamine signaling in the metazoan pathogenDisease models & mechanisms · 2018Article
- Multiple Biogenic Amine Receptor Types Modulate Spider,Frontiers in physiology · 2018Article
- Identification of multiple functional receptors for tyramine on an insect secretory epithelium.Scientific reports · 2017Article
- PeaTAR1B: Characterization of a Second Type 1 Tyramine Receptor of the American Cockroach, Periplaneta americana.International journal of molecular sciences · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A cloned seven transmembrane-spanning Drosophila octopamine/tyramine receptor, permanently expressed in a Chinese hamster ovary cell line, both inhibits adenylate cyclase activity and leads to the elevation of intracellular Ca2+ levels by separate G-protein-coupled pathways. Agonists of this receptor (octopamine and tyramine), differing by only a single hydroxyl group in their side chain, may be capable of differentially coupling it to different second messenger systems. Thus, a single receptor may have a different pharmacological profile depending on which second messenger system is used to assay its efficacy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.