ArticleThe Biochemical journal1994
Effects of oxidative stress on expression of extracellular superoxide dismutase, CuZn-superoxide dismutase and Mn-superoxide dismutase in human dermal fibroblasts.
Article in The Biochemical journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 107 citations in OpenAlex.
- Antioxidants Supplementation in Acute Amitriptyline Abuse for Pain.Applied biochemistry and biotechnology · 2022Trial
- Dose-Dependent Effects of Astaxanthin on Ischemia/Reperfusion Induced Brain Injury in MCAO Model Rat.Neurochemical research · 2022Article
- ThioredoxinA1 Controls the Oxidative Stress Response of Francisella tularensis Live Vaccine Strain (LVS).Journal of bacteriology · 2022Article
- Reactive Oxygen Species and Pressure Ulcer Formation after Traumatic Injury to Spinal Cord and Brain.Antioxidants (Basel, Switzerland) · 2021Review
- Identification and Molecular Characterization of Superoxide Dismutases Isolated From A Scuticociliate Parasite: Physiological Role in Oxidative Stress.Scientific reports · 2019Article
- Temporal expression profiling of plasma proteins reveals oxidative stress in early stages of Type 1 Diabetes progression.Journal of proteomics · 2018Article
- αFrontiers in physiology · 2018Article
- Extracellular superoxide dismutase and its role in cancer.Free radical biology & medicine · 2017Review
- Focus on molecular events in the anterior chamber leading to glaucoma.Cellular and molecular life sciences : CMLS · 2014Review
- Characterization of superoxide dismutases in cardiac progenitor cells demonstrates a critical role for manganese superoxide dismutase.Stem cells and development · 2012Article
- Mathematical and computational models of oxidative and nitrosative stress.Critical reviews in biomedical engineering · 2011Review
- Inflammatory cytokine induced regulation of superoxide dismutase 3 expression by human mesenchymal stem cells.Stem cell reviews and reports · 2010Article
- Gene expressions of Mn-SOD and GPx-1 in streptozotocin-induced diabetes: effect of antioxidants.Molecular and cellular biochemistry · 2009Article
- Extracellular superoxide dismutase (ecSOD) in vascular biology: an update on exogenous gene transfer and endogenous regulators of ecSOD.Translational research : the journal of laboratory and clinical medicine · 2008Review
- Article
- Human macrophages limit oxidation products in low density lipoprotein.Lipids in health and disease · 2005Article
- Implications for oxidative and nitrative stress in the pathogenesis of AIDS-related Kaposi's sarcoma.Carcinogenesis · 2004Article
- Up-regulation of base excision repair correlates with enhanced protection against a DNA damaging agent in mouse cell lines.Nucleic acids research · 1998Article
- Circulating plasma xanthine oxidase contributes to vascular dysfunction in hypercholesterolemic rabbits.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Characterization of the manganese superoxide dismutase cDNA and gene from the human parasite Onchocerca volvulus.The Biochemical journal · 1995Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To determine the effect of oxidative stress on expression of extracellular superoxide dismutase (EC-SOD), CuZn-SOD and Mn-SOD, two fibroblast lines were exposed for periods of up to 4 days to a wide concentration range of oxidizing agents: xanthine oxidase plus hypoxanthine, paraquat, pyrogallol, alpha-naphthoflavone, hydroquinone, catechol, Fe2+ ions, Cu2+ ions, buthionine sulphoximine, diethylmaleate, t-butyl hydroperoxide, cumene hydroperoxide, selenite, citiolone and high oxygen partial pressure. The cell lines were cultured both under serum starvation and at a serum concentration that permitted growth. Under no condition was there any evidence of EC-SOD induction. Instead, the agents uniformly, dose-dependently and continuously reduced EC-SOD expression. We interpret the effect to be due to toxicity. Enhancement of the protection against oxidative stress by addition of CuZn-SOD, catalase and low concentrations of selenite did not influence the expression of any of the SOD isoenzymes. Removal of EC-SOD from cell surfaces by heparin also did not influence SOD expression. Mn-SOD was moderately induced by high doses of the first 11 oxidants. Apart from reduction at high toxic doses, there were no significant effects on the CuZn-SOD activity by any of the treatments. Thus EC-SOD, previously shown to be profoundly influenced by inflammatory cytokines, was not induced by its substrate or other oxidants. In a similar fashion, Mn-SOD, previously shown to be greatly induced and depressed by cytokines, was only moderately influenced by oxidants. We suggest that the regulation of these SOD isoenzymes in mammalian tissues primarily occurs in a manner co-ordinated by cytokines, rather than as a response of individual cells to oxidants.
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