ArticleProceedings of the National Academy of Sciences of the United States of America1994
Mutations in PRG1, a yeast proteasome-related gene, cause defects in nuclear division and are suppressed by deletion of a mitotic cyclin gene.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 25 citations in OpenAlex.
- Proteasome Subunits Differentially Control Myeloma Cell Viability and Proteasome Inhibitor Sensitivity.Molecular cancer research : MCR · 2020Article
- Subcellular distribution of proteasomes implicates a major location of protein degradation in the nuclear envelope-ER network in yeast.The EMBO journal · 1998Article
- Inhibitors of nuclear factor kappa B cause apoptosis in cultured macrophages.Mediators of inflammation · 1997Article
- Plant 21D7 protein, a nuclear antigen associated with cell division, is a component of the 26S proteasome.Plant physiology · 1997Article
- Yeast counterparts of subunits S5a and p58 (S3) of the human 26S proteasome are encoded by two multicopy suppressors of nin1-1.Molecular biology of the cell · 1997Article
- The yeast nuclear import receptor is required for mitosis.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Biogenesis, structure and function of the yeast 20S proteasome.The EMBO journal · 1995Article
- [Proteasomes. Complex proteases lead to a new understanding of cellular regulation through proteolysis].Die Naturwissenschaften · 1995Review
- Proteasomes of the yeast S. cerevisiae: genes, structure and functions.Molecular biology reports · 1995Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Proteasomes are ubiquitous complexes exhibiting proteolytic activity in vitro. The function(s) of these enzymes in vivo is not known. To investigate the in vivo role of proteasomes, four temperature-sensitive alleles of the Saccharomyces cerevisiae proteasome-related gene, PRG1, were constructed and analyzed. At both the permissive and restrictive temperatures, many prg1 cells have a large bud, contain replicated DNA, and have their nucleus positioned at the neck with a short spindle. These different phenotypes indicate a defect in nuclear division. Consistent with a nuclear division defect, prg1 mutant strains lose a dispensable chromosome at a higher frequency than wild-type cells. Importantly, deletion of CLB2, a gene encoding a mitotic cyclin, suppresses the temperature-sensitive growth phenotype of prg1 mutant strains. Our results indicate that proteasomes are important for nuclear division and suggest that they participate in degradation of the Clb2 protein (Clb2p).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.