ArticlePflugers Archiv : European journal of physiology1993
Effect of 2,3-butanedione monoxime on smooth-muscle contraction of guinea-pig portal vein.
Article in Pflugers Archiv : European journal of physiology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 14 citations in OpenAlex.
- Inhibitors of myosin, but not actin, alter transport through Tradescantia plasmodesmata.Protoplasma · 2011Article
- Blebbistatin: use as inhibitor of muscle contraction.Pflugers Archiv : European journal of physiology · 2008Article
- Force-inhibiting effect of okadaic acid on skinned rat uterus permeabilized with alpha-toxin.Pflugers Archiv : European journal of physiology · 1995Article
- Comparison of the effects of 2,3-butanedione monoxime on force production, myosin light chain phosphorylation and chemical energy usage in intact and permeabilized smooth and skeletal muscles.Journal of muscle research and cell motility · 1994Article
- Effect of 2,3-butanedione monoxime on smooth-muscle contraction of guinea-pig portal vein.Pflugers Archiv : European journal of physiology · 1993Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
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Abstract
Effects of 2,3-butanedione-2-monoxime (BDM) on the contraction of intact and skinned smooth muscles from guinea-pig portal vein were examined. In intact preparations loaded with fura-2, 5-10 mM BDM markedly suppressed Ca2+ transients and force developments induced by 154 mM potassium and by phenylephrine (0.1 mM). On the other hand, in Ca(2+)-free depolarizing solution, BDM did not suppress phenylephrine (0.1 mM)-induced Ca2+ transient and force development. In skinned preparations obtained with Staphylococcus aureus alpha-toxin treatment, BDM did not markedly affect active force development. The above results indicate that BDM suppresses contraction of the portal vein mainly by the inhibition of voltage-dependent cytosolic Ca2+ transients. An additional result suggests that BDM suppresses the force-enhancing effect of alpha 1-adrenergic agents on the contractile elements.
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