ArticleNaunyn-Schmiedeberg's archives of pharmacology1993
Evans blue blocks P2X-purinoceptors in rat vas deferens.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 40 citations in OpenAlex.
- ATP: The crucial component of secretory vesicles.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Effects of exogenous nicotinamide adenine dinucleotide (NAD+) in the rat heart are mediated by P2 purine receptors.Journal of biomedical science · 2016Article
- Expression and function of the epithelial sodium channel δ-subunit in human respiratory epithelial cells in vitro.Pflugers Archiv : European journal of physiology · 2015Article
- De novo expression of connexin hemichannels in denervated fast skeletal muscles leads to atrophy.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- P2-purinoceptor antagonists: II. Blockade of P2-purinoceptor subtypes and ecto-nucleotidases by compounds related to Evans blue and trypan blue.Naunyn-Schmiedeberg's archives of pharmacology · 1996Article
- P2-purinoceptor antagonists: III. Blockade of P2-purinoceptor subtypes and ecto-nucleotidases by compounds related to suramin.Naunyn-Schmiedeberg's archives of pharmacology · 1996Article
- Evaluation of P2-purinoceptor antagonists at two relaxation-mediating P2-purinoceptors in guinea-pig taenia coli.Naunyn-Schmiedeberg's archives of pharmacology · 1996Article
- Failure of tyramine to release neuronal ATP as a cotransmitter of noradrenaline in the guinea-pig vas deferens.Naunyn-Schmiedeberg's archives of pharmacology · 1996Article
- New insights on P2X purinoceptors.Naunyn-Schmiedeberg's archives of pharmacology · 1995Review
- Reactive red 2: a P2y-selective purinoceptor antagonist and an inhibitor of ecto-nucleotidase.Naunyn-Schmiedeberg's archives of pharmacology · 1995Article
- Mechanism of bradykinin-induced plasma extravasation in the rat knee joint.British journal of pharmacology · 1995Article
- Functional consequences of inhibition of nucleotide breakdown in rat vas deferens: a study with Evans blue.Naunyn-Schmiedeberg's archives of pharmacology · 1995Article
- Blockade of P2X-purinoceptors by trypan blue in rat vas deferens.British journal of pharmacology · 1994Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In rat vas deferens, Evans blue 100 microM increased contractions elicited by high K+ and by noradrenaline but markedly reduced contractions elicited by the P2X-purinoceptor-selective agonist alpha,beta-methylene ATP (3 microM). The concentration-response curve of alpha,beta-methylene ATP was shifted to the right by Evans blue 30 microM and the maximal contraction was increased. In tissues incubated with nifedipine 10 microM, Evans blue 100 microM tended to increase the residual contraction elicited by noradrenaline and abolished the residual response to alpha, beta-methylene ATP (3 microM). The concentration-response curve of alpha,beta-methylene ATP was progressively shifted to the right by increasing concentrations of Evans blue in the presence of nifedipine; maximal contractions were increased by Evans blue 10 and 30 but not 100 microM. From the shifts to the right caused by Evans blue 30 microM, apparent pKB values of 5.9 (no nifedipine) and 6.0 (nifedipine present) were calculated. It is concluded that Evans blue blocks P2X-purinoceptors in rat vas deferens and in addition causes a non-receptor-specific enhancement of contractions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.