ArticleThe Journal of clinical investigation1994
Skeletal muscle protein tyrosine phosphatase activity and tyrosine phosphatase 1B protein content are associated with insulin action and resistance.
Article in The Journal of clinical investigation, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 120 citations in OpenAlex.
- Targeting Protein Tyrosine Phosphatase 1B: Recent Advances in Natural, Synthetic, and Multitarget Inhibitors for Diabetes Therapy.Biomolecules · 2026Review
- Hyperinsulinemia and Its Pivotal Role in Aging, Obesity, Type 2 Diabetes, Cardiovascular Disease and Cancer.International journal of molecular sciences · 2021Review
- Exercise Counterbalances Rho/ROCK2 Signaling Impairment in the Skeletal Muscle and Ameliorates Insulin Sensitivity in Obese Mice.Frontiers in immunology · 2021Article
- Anti-Diabetic and Anti-Inflammatory Effects of Green and Red Kohlrabi Cultivars (Brassica oleracea var. gongylodes).Preventive nutrition and food science · 2014Article
- Norathyriol reverses obesity- and high-fat-diet-induced insulin resistance in mice through inhibition of PTP1B.Diabetologia · 2014Article
- Ventromedial hypothalamus-specific Ptpn1 deletion exacerbates diet-induced obesity in female mice.The Journal of clinical investigation · 2014Article
- Leptin signaling in skeletal muscle after bed rest in healthy humans.European journal of applied physiology · 2014Article
- Development of endometrial carcinoma in a patient with leprechaunism (donohue syndrome).Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2013Article
- Skeletal muscle protein tyrosine phosphatase 1B regulates insulin sensitivity in African Americans.Diabetes · 2012Article
- An extract of Artemisia dracunculus L. enhances insulin receptor signaling and modulates gene expression in skeletal muscle in KK-A(y) mice.The Journal of nutritional biochemistry · 2011Article
- Mediation of Endogenous β-Endorphin in the Plasma Glucose-Lowering Action of Herbal Products Observed in Type 1-Like Diabetic Rats.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Hepatic PTP1B Deficiency: The Promise of a Treatment for Metabolic Syndrome?Journal of clinical metabolism & diabetes · 2010Article
- Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo.The Journal of biological chemistry · 2008Article
- Increased hypothalamic protein tyrosine phosphatase 1B contributes to leptin resistance with age.Endocrinology · 2007Article
- Rosiglitazone ameliorates abnormal expression and activity of protein tyrosine phosphatase 1B in the skeletal muscle of fat-fed, streptozotocin-treated diabetic rats.British journal of pharmacology · 2005Article
- Structure-based prediction of free energy changes of binding of PTP1B inhibitors.Journal of computer-aided molecular design · 2003Article
- Pulling strings below the surface: hormone receptor signaling through inhibition of protein tyrosine phosphatases.Endocrine · 2001Review
- Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice.Molecular and cellular biology · 2000Article
- Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats.The Journal of clinical investigation · 1999 · on this mapArticle
- Insulin stimulates the tyrosine dephosphorylation of docking protein p130cas (Crk-associated substrate), promoting the switch of the adaptor protein crk from p130cas to newly phosphorylated insulin receptor substrate-1.The Biochemical journal · 1998Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Particulate and cytosolic protein tyrosine phosphatase (PTPase) activity was measured in skeletal muscle from 15 insulin-sensitive subjects and 5 insulin-resistant nondiabetic subjects, as well as 18 subjects with non-insulin-dependent diabetes mellitus (NIDDM). Approximately 90% of total PTPase activity resided in the particulate fraction. In comparison with lean nondiabetic subjects, particulate PTPase activity was reduced 21% (P < 0.05) and 22% (P < 0.005) in obese nondiabetic and NIDDM subjects, respectively. PTPase1B protein levels were likewise decreased by 38% in NIDDM subjects (P < 0.05). During hyperinsulinemic glucose clamps, glucose disposal rates (GDR) increased approximately sixfold in lean control and twofold in NIDDM subjects, while particulate PTPase activity did not change. However, a strong positive correlation (r = 0.64, P < 0.001) existed between particulate PTPase activity and insulin-stimulated GDR. In five obese NIDDM subjects, weight loss of approximately 10% body wt resulted in a significant and corresponding increase in both particulate PTPase activity and insulin-stimulated GDR. These findings indicate that skeletal muscle particulate PTPase activity and PTPase1B protein content reflect in vivo insulin sensitivity and are reduced in insulin resistant states. We conclude that skeletal muscle PTPase activity is involved in the chronic, but not acute regulation of insulin action, and that the decreased enzyme activity may have a role in the insulin resistance of obesity and NIDDM.
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Registered trials
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