ArticleThe Journal of cell biology1994
Intrinsic microtubule stability in interphase cells.
Article in The Journal of cell biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 113 citations in OpenAlex.
- Measurements of neurite extension and nucleokinesis in an iPSC-derived model system following microtubule perturbation.Molecular biology of the cell · 2025Article
- Stable GDP-tubulin islands rescue dynamic microtubules.The Journal of cell biology · 2024Article
- The microtubule cytoskeleton: An old validated target for novel therapeutic drugs.Frontiers in pharmacology · 2022Review
- Article
- HDAC6 regulates microtubule stability and clustering of AChRs at neuromuscular junctions.The Journal of cell biology · 2020Article
- Structural basis of tubulin detyrosination by the vasohibin-SVBP enzyme complex.Nature structural & molecular biology · 2019Article
- Slow Release of HIV-1 Protein Nef from Vesicle-like Structures Is Inhibited by Cytosolic Calcium Elevation in Single Human Microglia.Molecular neurobiology · 2019Article
- Two-step interphase microtubule disassembly aids spindle morphogenesis.BMC biology · 2018Article
- Small molecules targeted to the microtubule-Hec1 interaction inhibit cancer cell growth through microtubule stabilization.Oncogene · 2018Article
- HeLife · 2017Article
- LIM kinases: cofilin and beyond.Oncotarget · 2017Review
- Rotavirus replication is correlated with S/G2 interphase arrest of the host cell cycle.PloS one · 2017Article
- Mitochondrial respiration is sensitive to cytoarchitectural breakdown.Integrative biology : quantitative biosciences from nano to macro · 2016Article
- Combretastatin A-4 derived imidazoles show cytotoxic, antivascular, and antimetastatic effects based on cytoskeletal reorganisation.Investigational new drugs · 2015Article
- Deoxypodophyllotoxin induces G2/M cell cycle arrest and apoptosis in SGC-7901 cells and inhibits tumor growth in vivo.Molecules (Basel, Switzerland) · 2015Article
- Structural basis for the association of MAP6 protein with microtubules and its regulation by calmodulin.The Journal of biological chemistry · 2013Article
- MAP6-F is a temperature sensor that directly binds to and protects microtubules from cold-induced depolymerization.The Journal of biological chemistry · 2012Article
- Mutation of Ser172 in yeast β tubulin induces defects in microtubule dynamics and cell division.PloS one · 2010Article
- Importance of non-selective cation channel TRPV4 interaction with cytoskeleton and their reciprocal regulations in cultured cells.PloS one · 2010Article
- Growth and tumor suppressor NORE1A is a regulatory node between Ras signaling and microtubule nucleation.The Journal of biological chemistry · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interphase microtubule arrays are dynamic in intact cells under normal conditions and for this reason they are currently assumed to be composed of polymers that are intrinsically labile, with dynamics that correspond to the behavior of microtubules assembled in vitro from purified tubulin preparations. Here, we propose that this apparent lability is due to the activity of regulatory effectors that modify otherwise stable polymers in the living cell. We demonstrate that there is an intrinsic stability in the microtubule network in a variety of fibroblast and epithelial cells. In the absence of regulatory factors, fibroblast cell interphase microtubules are for the most part resistant to cold temperature exposure, to dilution-induced disassembly and to nocodazole-induced disassembly. In epithelial cells, microtubules are cold-labile, but otherwise similar in behavior to polymers observed in fibroblast cells. Factors that regulate stability of microtubules appear to include Ca2+ and the p34cdc2 protein kinase. Indeed, this kinase induced complete destabilization of microtubules when applied to lysed cells, while a variety of other protein kinases were ineffective. This suggests that p34cdc2, or a kinase of similar specificity, may phosphorylate and inactivate microtubule-associated proteins, thereby conferring lability to otherwise length-wise stabilized microtubules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.