ArticleThe Journal of cell biology1994
Tyrosine kinase inhibitors can differentially inhibit integrin-dependent and CAM-stimulated neurite outgrowth.
Article in The Journal of cell biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 126 citations in OpenAlex.
- Antagonists of the N-cadherin/Fibroblast growth factor receptor tyrosine kinase complex.Tissue barriers · 2026Review
- The Function of FGFR1 Signalling in the Spinal Cord: Therapeutic Approaches Using FGFR1 Ligands after Spinal Cord Injury.Neural plasticity · 2017Review
- Overexpression of the Fibroblast Growth Factor Receptor 1 (FGFR1) in a Model of Spinal Cord Injury in Rats.PloS one · 2016Article
- Cellular strategies of axonal pathfinding.Cold Spring Harbor perspectives in biology · 2010Review
- Neuritogenic and neuroprotective properties of peptide agonists of the fibroblast growth factor receptor.International journal of molecular sciences · 2010Review
- Loss of glutamatergic pyramidal neurons in frontal and temporal cortex resulting from attenuation of FGFR1 signaling is associated with spontaneous hyperactivity in mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Intracellular signaling by the neural cell adhesion molecule.Neurochemical research · 2003Review
- Transmission of growth cone traction force through apCAM-cytoskeletal linkages is regulated by Src family tyrosine kinase activity.The Journal of cell biology · 2001Article
- A Src-astic response to mounting tension.The Journal of cell biology · 2001Review
- A short segment within the cytoplasmic domain of the neural cell adhesion molecule (N-CAM) is essential for N-CAM-induced NF-kappa B activity in astrocytes.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Article
- N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression.The Journal of cell biology · 1999Article
- Neurite outgrowth stimulated by neural cell adhesion molecules requires growth-associated protein-43 (GAP-43) function and is associated with GAP-43 phosphorylation in growth cones.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- NRP/B, a novel nuclear matrix protein, associates with p110(RB) and is involved in neuronal differentiation.The Journal of cell biology · 1998Article
- The role of glycoproteins in neural development function, and disease.Molecular neurobiology · 1998Review
- Domain requirements for the Dock adapter protein in growth- cone signaling.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Tyrosine phosphorylation at a site highly conserved in the L1 family of cell adhesion molecules abolishes ankyrin binding and increases lateral mobility of neurofascin.The Journal of cell biology · 1997Article
- Cell adhesion molecules NgCAM and axonin-1 form heterodimers in the neuronal membrane and cooperate in neurite outgrowth promotion.The Journal of cell biology · 1996Article
- Intracellular signaling is changed after clustering of the neural cell adhesion molecules axonin-1 and NgCAM during neurite fasciculation.The Journal of cell biology · 1996Article
- Association between a transmembrane protein tyrosine phosphatase and the cadherin-catenin complex.The Journal of cell biology · 1996Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have used monolayers of parental 3T3 cells and 3T3 cells expressing one of three transfected cell adhesion molecules (CAMs) (NCAM, N-cadherin, and L1) as a culture substrate for rat cerebellar neurons. A number of tyrosine kinase inhibitors have been tested for their ability to inhibit neurite outgrowth over parental 3T3 monolayers which we show to be partly dependent on neuronal integrin receptor function, as compared with neurite outgrowth stimulated by the above three CAMs. Whereas genistein (100 microM), lavendustin A (20 microM), and tyrphostins 34 and 47 (both at 150 microM) had no effect on integrin dependent or CAM stimulated neurite outgrowth, the erbstatin analogue (10-15 micrograms/ml) and tyrphostins 23 and 25 (both at 150 microM) specifically inhibited the response stimulated by all three CAMs. CAM stimulated neurite outgrowth can be accounted for by a G-protein-dependent activation of neuronal calcium channels; experiments with agents that directly activate this pathway localized the erbstatin analogue site of action upstream of the G-protein and calcium channels, whereas tyrphostins have sites of action downstream from calcium channel activation. These data suggest that activation of an erbstatin sensitive tyrosine kinase is an important step upstream of calcium channel activation in the second messenger pathway underlying the neurite outgrowth response stimulated by a variety of CAMs, and that this kinase is not required for integrin-dependent neurite outgrowth.
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