ArticleImmunology1994
Role of tumour necrosis factor-alpha in ultraviolet B light-induced dendritic cell migration and suppression of contact hypersensitivity.
Article in Immunology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 99 citations in OpenAlex.
- Crosslinking of Ly6a metabolically reprograms CD8 T cells for cancer immunotherapy.Nature communications · 2024Article
- Cytotoxic Effects of Ethanolic Extract of Polypodium Vulgare on Human Malignant Melanoma Cell Line.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- TNF blockade enhances the efficacy of myxoma virus-based oncolytic virotherapy.Journal for immunotherapy of cancer · 2022Article
- Exposure to solar ultraviolet radiation establishes a novel immune suppressive lipidome in skin-draining lymph nodes.Frontiers in immunology · 2022Article
- Ultraviolet Radiation and Melanomagenesis: From Mechanism to Immunotherapy.Frontiers in oncology · 2020Review
- Oral administration of lipoteichoic acid from Lactobacillus rhamnosus GG overcomes UVB-induced immunosuppression and impairs skin tumor growth in mice.European journal of immunology · 2019Article
- Epidermal PPARγ influences subcutaneous tumor growth and acts through TNF-α to regulate contact hypersensitivity and the acute photoresponse.Oncotarget · 2017Article
- Trans-nodal migration of resident dendritic cells into medullary interfollicular regions initiates immunity to influenza vaccine.The Journal of experimental medicine · 2014Article
- Article
- Photoimmunology--illuminating the immune system through photobiology.Seminars in immunopathology · 2007Review
- Role of the parasite-derived prostaglandin D2 in the inhibition of epidermal Langerhans cell migration during schistosomiasis infection.The Journal of experimental medicine · 2001Article
- Regulation of epidermal Langerhans cell migration by lactoferrin.Immunology · 2000Article
- Localization of DNA damage and its role in altered antigen-presenting cell function in ultraviolet-irradiated mice.The Journal of experimental medicine · 1996Article
- The role of dendritic cells in cutaneous immunity.Archives of dermatological research · 1996Review
- Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.The Journal of experimental medicine · 1995Article
- Ultraviolet B-induced inflammatory cytokine production, in vivo: initial pharmacological characterization.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 1995Article
- Tumour necrosis factor-alpha is required for accumulation of dendritic cells in draining lymph nodes and for optimal contact sensitization.Immunology · 1995Article
- DNA damage, apoptosis and langerhans cells--Activators of UV-induced immune tolerance.Photochemistry and photobiologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Irradiation with ultraviolet B light (UVB) is known to suppress contact and delayed hypersensitivity response to a variety of antigens encountered within a short period following exposure. Such irradiation results in loss of Langerhans' cells and in synthesis of tumour necrosis factor-alpha (TNF-alpha) in the epidermis. In the present study the effect of broad-band (270-350 nm) and narrow-band (311-312 nm) UVB on the induction of contact hypersensitivity (CH) and on dendritic cell (DC) numbers in draining lymph nodes (DLN) of mice was examined. Broad-band UVB induced the accumulation of DC in DLN and this increase was substantially abrogated by treatment of mice with neutralizing antibody to TNF-alpha before irradiation. In addition, irradiation before sensitization with oxazolone resulted in a suppressed CH response. The suppression was negated to a considerable extent by TNF-alpha antibodies, administered before irradiation. Thus, one of the major effects of broad-band UVB is likely to be the synthesis of epidermal TNF-alpha which, in turn induces the migration of Langerhans' cells to DLN and leads to an impairment of their activity or function. Conversely narrow-band UVB did not result in an accumulation of DC in DLN or in a suppressed CH response. Such irradiation does, however, cause the isomerization from trans to cis-UCA in the epidermis. Cis-UCA has been proposed as a photoreceptor for UV and suppresses immune responses in a variety of experimental systems. Thus cis-UCA does not act through TNF-alpha induction or by influencing DC migration, and other studies indicate that histamine-like receptors in the skin may be involved.
Indexed as
Identifiers
8132224PMC1422292W114807376What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.