ArticleThe Biochemical journal1994
Targeting of c-myc and beta-globin coding sequences to cytoskeletal-bound polysomes by c-myc 3' untranslated region.
Article in The Biochemical journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 62 citations in OpenAlex.
- Fine mapping of interactions between eEF1alpha protein and 3'UTR of metallothionein-1 mRNA.Biochemical and biophysical research communications · 2009Article
- Elongation factor 1alpha binds to the region of the metallothionein-1 mRNA implicated in perinuclear localization--importance of an internal stem-loop.RNA (New York, N.Y.) · 2006Article
- An AU-rich stem-loop structure is a critical feature of the perinuclear localization signal of c-myc mRNA.The Biochemical journal · 2005Article
- An eleven nucleotide section of the 3'-untranslated region is required for perinuclear localization of rat metallothionein-1 mRNA.The Biochemical journal · 2005Article
- Distinct regions in the 3' untranslated region are responsible for targeting and stabilizing utrophin transcripts in skeletal muscle cells.The Journal of cell biology · 2001Article
- Influence of metallothionein-1 localization on its function.The Biochemical journal · 2001Article
- Competition between the signal sequence and a 3'UTR localisation signal during redirection of beta-globin mRNA to the endoplasmic reticulum: implications for biotechnology.Cytotechnology · 1999Article
- Expansion of a CUG trinucleotide repeat in the 3' untranslated region of myotonic dystrophy protein kinase transcripts results in nuclear retention of transcripts.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Exon 2-mediated c-myc mRNA decay in vivo is independent of its translation.Molecular and cellular biology · 1996Article
- Testis/brain RNA-binding protein attaches translationally repressed and transported mRNAs to microtubules.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- mRNA stability in mammalian cells.Microbiological reviews · 1995Review
- The mRNAs for cyclin A, c-myc and ribosomal proteins L4 and S6 are associated with cytoskeletal-bound polysomes in HepG2 cells.The Biochemical journal · 1995Article
- Changes in distribution of actin mRNA in different polysome fractions following stimulation of MPC-11 cells.Molecular and cellular biochemistry · 1995Article
- Translation and the cytoskeleton: a mechanism for targeted protein synthesis.Molecular biology reports · 1994Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The influence of the 3' untranslated region on mRNA localization was investigated by measuring the distribution of myc, beta-globin and hybrid myc-globin mRNAs between free, cytoskeletal-bound and membrane-bound polysomes in cells transfected with either control or chimeric gene constructs. c-myc sequences and beta-globin-coding sequences linked to the myc 3' untranslated region were present at greatest enrichment in cytoskeletal-bound polysomes. beta-Globin mRNA and myc-coding sequences linked to the beta-globin 3' untranslated region were recovered largely in the free polysomes. In situ hybridization confirmed that replacement of the c-myc 3' untranslated region by that of globin caused a relocalization of the mRNA. The results suggest that mRNA localization in differentiated eukaryotic cells depends on a mechanism that involves directional information in the 3' untranslated region of mRNAs.
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