ArticleThe American journal of pathology1994
Increased expression of the 72-kd type IV collagenase in prostatic adenocarcinoma. Demonstration by immunohistochemistry and in situ hybridization.
Article in The American journal of pathology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 72 citations in OpenAlex.
- Claudin-4 expression in gastric cancer cells enhances the invasion and is associated with the increased level of matrix metalloproteinase-2 and -9 expression.Oncology letters · 2014Article
- Roles of matrix metalloproteinases and their natural inhibitors in prostate cancer progression.Cancers · 2014Article
- Claudin-4 expression is associated with tumor invasion, MMP-2 and MMP-9 expression in gastric cancer.Experimental and therapeutic medicine · 2010Article
- Usefulness of MMP-9/TIMP-1 in predicting tumor recurrence in patients undergoing curative surgical resection for gastric carcinoma.Digestive diseases and sciences · 2007Article
- Identification of degradome components associated with prostate cancer progression by expression analysis of human prostatic tissues.British journal of cancer · 2005Article
- Matrix metalloproteinases as diagnostic (MMP-13) and prognostic (MMP-2, MMP-9) markers of prostate cancer.Urological research · 2005Article
- Expression of matrix metalloproteinases (MMP-2 and -9) and their inhibitors (TIMP-1 and -2) in prostate cancer tissue.Prostate cancer and prostatic diseases · 2003Article
- Increased type-IV collagenase (MMP-2 and MMP-9) activity following preoperative radiotherapy in rectal cancer.British journal of cancer · 2000Article
- Review
- Article
- Loss of type IV collagen alpha 5 and alpha 6 chains in human invasive prostate carcinomas.The American journal of pathology · 1997Article
- Matrix metalloproteinases. Novel targets for directed cancer therapy.Drugs & aging · 1997Review
- Correlation of metastasis-related gene expression with metastatic potential in human prostate carcinoma cells implanted in nude mice using an in situ messenger RNA hybridization technique.The American journal of pathology · 1997Article
- Expression of interstitial collagenase (matrix metalloproteinase-1) in gastric cancers.Japanese journal of cancer research : Gann · 1997Article
- Multiparametric in situ mRNA hybridization analysis to predict disease recurrence in patients with colon carcinoma.The American journal of pathology · 1996Article
- Sequential activation and production of matrix metalloproteinase-2 during breast cancer progression.Clinical & experimental metastasis · 1996Article
- In situ mRNA hybridization technique for analysis of metastasis-related genes in human colon carcinoma cells.The American journal of pathology · 1995Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The expression of the 72-kd type IV collagenase has been implicated as an important factor in determining the invasive potential of malignant tumors. Using immunohistochemistry and nonisotopic in situ hybridization, type IV collagenase expression was assessed in benign and malignant prostatic tissue obtained from 117 surgical and autopsy specimens. Diffuse strong staining for type IV collagenase mRNA and protein was identified in the malignant cells of more than 85% of prostatic adenocarcinomas and the dysplastic cells of high grade prostatic intraepithelial neoplasia. Benign hyperplastic epithelium showed moderate expression in basal cells and mild expression in secretory cells. The qualitative patterns of type IV collagenase expression in prostatic epithelium at the protein and mRNA levels in individual cases were identical. There was no correlation between the level of type IV collagenase expression and either tumor grade or stage. In 10% of adenocarcinomas, focal mild to moderate stromal cell immunoreactivity was present but mRNA was not detectable in the stromal compartment in any case. The enhanced expression of type IV collagenase in dysplastic epithelium and prostatic adenocarcinoma suggests it contributes to the development of the invasive phenotype. The vast majority of the enzyme present in these tumors is synthesized by malignant cells and its production by stromal cells is negligible.
Indexed as
Identifiers
8129044PMC1887101W304005486What OpenQuestion holds
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