ArticleAmerican journal of human genetics1994
Maximum-likelihood estimation of gene location by linkage disequilibrium.
Article in American journal of human genetics, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 73 papers.
What it found
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Who cites it
73 citing papers in PubMed.
- Integrated GWAS and Fst analysis identify flowering-time regulatory genes in maize.The plant genome · 2026Article
- Multi-Season Genome-Wide Association Study Reveals Loci and Candidate Genes for Fruit Quality and Maturity Traits in Peach.Plants (Basel, Switzerland) · 2026Article
- Characterization of Indian waxy and non-waxy maize germplasm for genetic differentiation through SNP genotyping.Molecular genetics and genomics : MGG · 2025Article
- Defaunation Increases Clustering and Fine-Scale Spatial Genetic Structure in a Small-Seeded Palm Despite Remaining Small-Bodied Frugivores.Molecular ecology · 2025Article
- Linkage Disequilibrium Decay in Selected Cattle Breeds.Animals : an open access journal from MDPI · 2024Article
- Linkage disequilibrium under polysomic inheritance.Heredity · 2022Article
- Linkage Disequilibrium and Effective Population Size of Buffalo Populations of Iran, Turkey, Pakistan, and Egypt Using a Medium Density SNP Array.Frontiers in genetics · 2021Article
- Genetic architecture of phenotypic means and plasticities of kernel size and weight in maize.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2019Article
- Stationary distribution of the linkage disequilibrium coefficient rTheoretical population biology · 2019Article
- On the Extent of Linkage Disequilibrium in the Genome of Farm Animals.Frontiers in genetics · 2019Review
- Genetic characterization of maize germplasm derived from Suwan population and temperate resources.Hereditas · 2019Article
- Assessing the degree of stratification between closely related Holstein-Friesian populations.Journal of applied genetics · 2017Article
- Article
- Analysis of genetic differentiation and genomic variation to reveal potential regions of importance during maize improvement.BMC plant biology · 2015Article
- Comparison of linkage disequilibrium levels in Iranian indigenous cattle using whole genome SNPs data.Journal of animal science and technology · 2015Article
- Genomic prediction based on runs of homozygosity.Genetics, selection, evolution : GSE · 2014Article
- Fine genetic characterization of elite maize germplasm using high-throughput SNP genotyping.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2014Article
- A robust and efficient statistical method for genetic association studies using case and control samples from multiple cohorts.BMC genomics · 2013Article
- Genome-wide haplotype changes produced by artificial selection during modern rice breeding in Japan.PloS one · 2012Article
- Investigation of CD28 gene polymorphisms in patients with sporadic breast cancer in a Chinese Han population in Northeast China.PloS one · 2012Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
Abstract
Linkage disequilibrium, D, between a polymorphic disease and mapped markers can, in principle, be used to help find the map position of the disease gene. Likelihoods are therefore derived for the value of D conditional on the observed number of haplotypes in the sample and on the population parameter Nc, where N is the effective population size and c the recombination fraction between the disease and marker loci. The likelihood is computed explicitly for the case of two loci with heterozygote superiority and, more generally, by computer simulations assuming a steady state of constant population size and selective pressures or neutrality. It is found that the likelihood is, in general, not very dependent on the degree of selection at the loci and is very flat. This suggests that precise information on map position will not be obtained from estimates of linkage disequilibrium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.