ArticleVeterinary immunology and immunopathology1994
Genetic variation in parameters reflecting immune competence of swine.
Article in Veterinary immunology and immunopathology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 88 citations in OpenAlex.
- Review
- Porcine genetic markers of immunocompetence shape the immune response to a classical swine fever virus subunit vaccine.Frontiers in cellular and infection microbiology · 2026Article
- Integrating large-scale meta-GWAS and PigGTEx resources to decipher the genetic basis of 232 complex traits in pigs.National science review · 2025Article
- Multivariate genome-wide associations for immune traits in two maternal pig lines.BMC genomics · 2023Article
- Fermented rye with Agaricus subrufescens and mannan-rich hydrolysate based feed additive to modulate post-weaning piglet immune response.Porcine health management · 2021Article
- Leveraging host-genetics and gut microbiota to determine immunocompetence in pigs.Animal microbiome · 2021Article
- Genome-wide associations for immune traits in two maternal pig lines.BMC genomics · 2021Article
- A Co-Association Network Analysis Reveals Putative Regulators for Health-Related Traits in Pigs.Frontiers in immunology · 2021Article
- Improvement of Disease Resistance in Livestock: Application of Immunogenomics and CRISPR/Cas9 Technology.Animals : an open access journal from MDPI · 2020Review
- Genetic parameters and associated genomic regions for global immunocompetence and other health-related traits in pigs.Scientific reports · 2020Article
- Identification of single-nucleotide variants associated with susceptibility to Salmonella in pigs using a genome-wide association approach.BMC veterinary research · 2020Article
- Genetic parameter estimates for plasma oxidative status traits in slaughter pigs.Journal of animal science · 2020Article
- Regulators of Salmonella-host interaction identified by peripheral blood transcriptome profiling: roles of TGFB1 and TRP53 in intracellular Salmonella replication in pigs.Veterinary research · 2018Article
- PBMC transcriptomic responses to primary and secondary vaccination differ due to divergent lean growth and antibody titers in a pig model.Physiological genomics · 2015Article
- Article
- Deciphering the genetic control of innate and adaptive immune responses in pig: a combined genetic and genomic study.BMC proceedings · 2011Article
- Article
- Article
- Mapping of quantitative trait loci for mycoplasma and tetanus antibodies and interferon-gamma in a porcine F(2) Duroc x Pietrain resource population.Mammalian genome : official journal of the International Mammalian Genome Society · 2010Article
- Traits associated with innate and adaptive immunity in pigs: heritability and associations with performance under different health status conditions.Genetics, selection, evolution : GSE · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic variation in total and differential white blood cell (WBC) counts, phagocytic capacity of polymorphonuclear leukocytes (PMNL), virus induced interferon-alpha (IFN-alpha) production, mitogen induced proliferation and interleukin 2 (IL-2) production of mononuclear cells (MNC) in vitro was studied in blood collected from 124 Yorkshire piglets, aged 8 weeks. The piglets were the offspring from 12 sires and 31 dams. Data from an earlier experiment, including 96 piglets of seven sires and 24 dams, were added when estimating heritabilities for Con A induced proliferation and IL-2 production. The highest heritability (h2 = 0.87 +/- 0.41) was estimated for the total number of PMNL. Medium high heritabilities (h2 = 0.3-0.4) were estimated for the phagocytic capacity of PMNL, Con A induced proliferation and IL-2 production and the total number of WBC, while the heritability estimates were lower (h2 = 0.00-0.08 +/- 0.12) for the total number of lymphocytes, serum concentrations of Ig and IFN-alpha production. Pronounced differences between litters from various dams were found for total number of lymphocytes, IFN-alpha production, Con A induced proliferation and IL-2 production. The Con A induced proliferation was positively correlated (r = 0.48, P < 0.001) with the IL-2 production and both these parameters were correlated (r = 0.44 and 0.37, respectively, P < 0.001) to the virus induced IFN-alpha production. Despite these positive correlations, no parental offspring group was uniformly superior across all traits measured. However, the heritabilities estimated for the immune parameters are sufficiently high to be used as genetic markers in selection for general immune competence of swine.
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