ArticleProceedings of the National Academy of Sciences of the United States of America1994
Expression and localization of amiloride-sensitive sodium channel indicate a role for non-taste cells in taste perception.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 63 citations in OpenAlex.
- Two-generation exposure to a high-fat diet induces the change of salty taste preference in rats.Scientific reports · 2023Article
- Does ENaC Work as Sodium Taste Receptor in Humans?Nutrients · 2020Review
- Genetics of taste receptors.Current pharmaceutical design · 2014Review
- Pragmatically on the sense of taste - a short treatise based on culinary art.Przeglad gastroenterologiczny · 2013Review
- Amiloride-sensitive channels in type I fungiform taste cells in mouse.BMC neuroscience · 2008Article
- Amiloride-sensitive NaCl taste responses are associated with genetic variation of ENaC alpha-subunit in mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2008Article
- DEG/ENaC ion channels involved in sensory transduction are modulated by cold temperature.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Electrophysiological characterization of a putative supporting cell isolated from the frog taste disk.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Self-inhibition in amiloride-sensitive sodium channels in taste receptor cells.The Journal of general physiology · 1998Article
- Development of membrane properties in taste cells of fungiform papillae: functional evidence for early presence of amiloride-sensitive sodium channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Distribution and characterization of functional amiloride-sensitive sodium channels in rat tongue.The Journal of general physiology · 1996Article
- Article
- Structure and function of amiloride-sensitive Na+ channels.The Journal of membrane biology · 1995Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salty taste is blocked by the diuretic amiloride, which inhibits specific sodium channels. We have isolated an amiloride-sensitive sodium channel (ASSC) from taste tissues by polymerase chain reaction and screening of a cDNA library prepared from rat circumvallate papillae. Northern analysis reveals ASSC in taste and non-taste tissues with the highest level of expression of ASSC in the lung. In situ hybridization establishes ASSC localizations in the epithelia of lung and colon as well as tongue epithelial layers containing and lacking taste buds. These results support a model in which ASSC in non-taste cells regulates responses of taste cells to salt as well as other tastants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.