ArticleProceedings of the National Academy of Sciences of the United States of America1994
Peroxisome proliferator and retinoid signaling pathways co-regulate preadipocyte phenotype and survival.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 228 citations in OpenAlex.
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- CD24 negativity reprograms mitochondrial metabolism to PPARα and NF-κB-driven fatty acid β-oxidation in triple-negative breast cancer.Cancer letters · 2024Article
- Study of the Interactions between Muscle Fatty Acid Composition, Meat Quality-Related Genes and the Ileum Microbiota in Tibetan Sheep at Different Ages.Foods (Basel, Switzerland) · 2024Article
- Navigating the Adipocyte Precursor Niche: Cell-Cell Interactions, Regulatory Mechanisms and Implications for Adipose Tissue Homeostasis.Journal of cellular signaling · 2024Article
- Circadian mechanisms in adipose tissue bioenergetics and plasticity.Genes & development · 2023Review
- Isoform-specific functions of PPARγ in gene regulation and metabolism.Genes & development · 2022Article
- Control of Adipose Cell Browning and Its Therapeutic Potential.Metabolites · 2020Review
- Isolation and Identification of Bovine Preadipocytes and Screening of MicroRNAs Associated with Adipogenesis.Animals : an open access journal from MDPI · 2020Article
- ALDH1A1 Inhibits Chicken Preadipocytes' Proliferation and Differentiation via the PPARγ Pathway In Vitro and In Vivo.International journal of molecular sciences · 2020Article
- The Beige Adipocyte as a Therapy for Metabolic Diseases.International journal of molecular sciences · 2019Review
- Long non-coding RNA slincRAD functions in methylation regulation during the early stage of mouse adipogenesis.RNA biology · 2019Article
- Patient Adipose Stem Cell-Derived Adipocytes Reveal Genetic Variation that Predicts Antidiabetic Drug Response.Cell stem cell · 2019Article
- Flow cytometry-based FRET identifies binding intensities in PPARγ1 protein-protein interactions in living cells.Theranostics · 2019Article
- Peroxisome Proliferator-Activated Receptor γ and Its Role in Adipocyte Homeostasis and Thiazolidinedione-Mediated Insulin Sensitization.Molecular and cellular biology · 2018Article
- The role of metabolic states in development and disease.Current opinion in genetics & development · 2017Review
- A PPARγ transcriptional cascade directs adipose progenitor cell-niche interaction and niche expansion.Nature communications · 2017Article
- The expanding problem of adipose depot remodeling and postnatal adipocyte progenitor recruitment.Molecular and cellular endocrinology · 2017Review
- Sorting out adipocyte precursors and their role in physiology and disease.Genes & development · 2017Review
- Emerging Roles of Adipose Progenitor Cells in Tissue Development, Homeostasis, Expansion and Thermogenesis.Trends in endocrinology and metabolism: TEM · 2016Review
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Culture of mouse 3T3-L1 preadipocytes in medium containing delipidated bovine calf serum caused the cells to elongate and divide after reaching confluency. The continued proliferation correlated with sustained expression of the c-myc gene, which was repressed in control cells. Exposure of the cells to activators of peroxisome proliferator-activated receptor (PPAR), including clofibrate, WY-14,643, and 5,8,11,14-eicosatetraynoic acid, reversed and prevented the effects of culturing preadipocytes in delipidated serum. Continued exposure to PPAR activators led to adipose conversion, during which PPAR and its heterodimerization partner (retinoid X receptor) were induced. Retinoic acid (RA) had no effect on the growth or survival of preadipocytes grown in the presence of normal bovine serum. However, treatment of cells cultured in delipidated serum with RA caused death of the cells by apoptosis. Thus, preadipocyte phenotype and survival are regulated by activators of nuclear hormone receptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.