ArticleNucleic acids research1994
Illegitimate recombination in Xenopus: characterization of end-joined junctions.
Article in Nucleic acids research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 71 citations in OpenAlex.
- Genome engineering with TALENs and ZFNs: repair pathways and donor design.Methods (San Diego, Calif.) · 2014Article
- Targeted DNA excision in Arabidopsis by a re-engineered homing endonuclease.BMC biotechnology · 2012Article
- Slow DNA loss in the gigantic genomes of salamanders.Genome biology and evolution · 2012Article
- Comparative genomics-based identification and analysis of cis-regulatory elements.Methods in molecular biology (Clifton, N.J.) · 2012Article
- Article
- Induction and repair of zinc-finger nuclease-targeted double-strand breaks in Caenorhabditis elegans somatic cells.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Targeted mutagenesis using zinc-finger nucleases in Arabidopsis.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- A 122.5-kilobase deletion of the P gene underlies the high prevalence of oculocutaneous albinism type 2 in the Navajo population.American journal of human genetics · 2003Article
- Efficient repair of genomic double-strand breaks by homologous recombination between directly repeated sequences in the plant genome.The Plant cell · 2002Article
- The role of DNA polymerase activity in human non-homologous end joining.Nucleic acids research · 2001Article
- Role of DNA ligase in the illegitimate recombination that generates lambdabio-transducing phages in Escherichia coli.Genetics · 2001Article
- DNA double-strand break repair in cell-free extracts from Ku80-deficient cells: implications for Ku serving as an alignment factor in non-homologous DNA end joining.Nucleic acids research · 2000Article
- Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes.The Journal of experimental medicine · 1999Article
- Capture of genomic and T-DNA sequences during double-strand break repair in somatic plant cells.The EMBO journal · 1998Article
- In vitro and in vivo reconstitution and stability of vertebrate chromosome ends.Nucleic acids research · 1998Article
- Non-homologous DNA end joining in plant cells is associated with deletions and filler DNA insertions.Nucleic acids research · 1997Article
- The Drosophila melanogaster RAD54 homolog, DmRAD54, is involved in the repair of radiation damage and recombination.Molecular and cellular biology · 1997Article
- Processing of DNA prior to illegitimate recombination in mouse cells.Molecular and cellular biology · 1997Article
- The RAD5 gene product is involved in the avoidance of non-homologous end-joining of DNA double strand breaks in the yeast Saccharomyces cerevisiae.Nucleic acids research · 1997Article
- Role of enzymes of homologous recombination in illegitimate plasmid recombination in Bacillus subtilis.Journal of bacteriology · 1997Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
When linear DNAs are injected into Xenopus laevis eggs, they are converted into several different kinds of recombination products. Some molecules undergo homologous recombination by a resection-annealing mechanism; some ends are precisely ligated; and some ends are joined by illegitimate means. The homologous and illegitimate products are also generated in nuclear extracts from stage VI Xenopus oocytes. In order to gain insight into the mechanism(s) of illegitimate end joining, we amplified, cloned and sequenced a number of junctions from eggs and from oocyte extracts. The egg junctions fell into three categories: some with no homology at the join point that may have been produced by blunt-end ligation; some based on small, but significant homologies (5-10 bp); and some with matches of only 1 or 2 nucleotides at the joint. Junctions made in oocyte extracts were largely of the latter type. In the extracts, formation of illegitimate joints required the addition of all four deoxyribonucleoside triphosphates and was inhibited by aphidicolin. This indicates that this process involves DNA synthesis, and mechanisms incorporating this feature are considered. The spectrum of recombination products formed in Xenopus eggs is very reminiscent of those produced from DNA introduced into mammalian cells.
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