ArticleNucleic acids research1994
Cloning and characterization of a single-stranded DNA binding protein that specifically recognizes deoxycytidine stretch.
Article in Nucleic acids research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 40 citations in OpenAlex.
- Surface PD-1 expression in T cells is suppressed by HNRNPK through an exonic splicing silencer on exon 3.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024Article
- hnRNPK recognition of the B motif of Xist and other biological RNAs.Nucleic acids research · 2020Article
- Transient recruitment of the hnRNP K protein to inducibly transcribed gene loci.Nucleic acids research · 2003Article
- Insulin alters heterogeneous nuclear ribonucleoprotein K protein binding to DNA and RNA.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- An enhancer trap screen for ecdysone-inducible genes required for Drosophila adult leg morphogenesis.Genetics · 2000Article
- The levels of the bancal product, a Drosophila homologue of vertebrate hnRNP K protein, affect cell proliferation and apoptosis in imaginal disc cells.Molecular and cellular biology · 1999Article
- Identification of AUF1 (heterogeneous nuclear ribonucleoprotein D) as a component of the alpha-globin mRNA stability complex.Molecular and cellular biology · 1997Article
- C/EBP factor suppression of inhibition of type II secreted phospholipase A2 promoter in HepG2 cells: possible role of single-strand binding proteins.Molecular and cellular biology · 1997Article
- Heterogeneous nuclear ribonucleoprotein K is a transcription factor.Molecular and cellular biology · 1996Article
- Single-strand-DNA-binding factors specifically recognize the pyrimidine element in the chick alpha2(I) collagen gene promoter.The Biochemical journal · 1996Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We previously identified a G-rich silencer element involved in negative regulation of catalase gene expression in some hepatoma cells (Mol. Cell. Biol., (1992), 12, 2525-2533). To study a nuclear binding protein for this element, we screened cDNA libraries from a rat ascites hepatoma cell line by binding with a synthetic oligonucleotide probe and obtained several clones. One of them, designated SW, was studied in detail. A clone (SW2) of this series contained a near full length cDNA encoding a putative peptide with 463 amino acid residues. We isolated this peptide as a fusion protein. It was found that the protein strongly bound to the C-stretch of the DNA sequence in a single strand specific fashion, but absolutely did not to G-rich sequence. The protein bound weakly to the corresponding double-stranded DNA as well as to C-rich RNA sequence. This protein, though not the expected one, was found to be a novel protein whose DNA binding domain was located on the region containing at least 75 amino acid residues of the carboxyl terminus. A proline rich region was also observed in the middle part of the protein. Northern blot profiles indicated extensive and slight expression of both 2.0 kb and 2.7 kb mRNA species in some hepatoma cell lines and in the rat liver, respectively.
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