Trial reportThe Clinical investigator1993
Hyperhomocysteinemia and the response to vitamin supplementation.
Trial report in The Clinical investigator, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Preventive health care, 2000 update: screening and management of hyperhomocysteinemia for the prevention of coronary artery disease events. The Canadian Task Force on Preventive Health Care.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2000Guideline
- Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. Homocysteine Lowering Trialists' Collaboration.BMJ (Clinical research ed.) · 1998Pooled it
- Effect of fortified spread on homocysteine concentration in apparently healthy volunteers.European journal of clinical nutrition · 2007Trial
- Hyperhomocysteinemia--a risk factor for abruptio placentae.Journal of inherited metabolic disease · 1997Trial
- Association of mid-pregnancy antioxidative vitamin and oxidative stress levels with infant growth during the first 3 years of life.Food & nutrition research · 2014Article
- Lowering homocysteine and modifying nutritional status with folic acid and vitamin B(12) in Indian patients of vascular disease.Journal of clinical biochemistry and nutrition · 2012Article
- A folate-rich diet is as effective as folic acid from supplements in decreasing plasma homocysteine concentrations.International journal of medical sciences · 2005Article
- Elevated plasma homocysteine is positively associated with age independent of C677T mutation of the methylenetetrahydrofolate reductase gene in selected Egyptian subjects.International journal of medical sciences · 2004Article
- Plasma homocysteine, methylene tetrahydrofolate reductase C677T and factor II G20210A polymorphisms, factor VIII, and VWF in central retinal vein occlusion.The British journal of ophthalmology · 2001Article
- Assessment of nutritional folate status and selected vitamin status of women of childbearing age.European journal of clinical nutrition · 2001Article
- Homocysteine, vitamins, and coronary artery disease. Comprehensive review of the literature.Canadian family physician Medecin de famille canadien · 2000Review
- [A young patient with multiple arterial occlusions].Medizinische Klinik (Munich, Germany : 1983) · 1998Article
- The role of vitamins in the pathogenesis and treatment of hyperhomocyst(e)inaemia.Journal of inherited metabolic disease · 1997Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The long-term vitamin requirements of men (n = 22) with moderate hyperhomocysteinemia (plasma total homocysteine concentration > 16.3 mumol/l) were investigated over a period of 48 weeks. An initial 6-week period of vitamin supplementation (1.0 mg folic acid, 10 mg pyridoxine, 0.05 mg cyanocobalamin) reduced plasma homocysteine levels 54.7% (P < 0.001). However, 18 weeks after vitamin therapy was discontinued, only seven participants (subgroup A) still had plasma homocysteine levels of 16.3 mumol/l or lower. The remainder of the participants (subgroup B) required a second 6-week period of vitamin therapy to normalize the elevated plasma homocysteine levels. Substitution of vitamin supplementation by dietary guidelines to increase folate intake from food products failed to maintain normal plasma homocysteine levels in participants from subgroup B. Long-term vitamin supplementation may be required in some individuals to prevent hyperhomocysteinemia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.