ArticleBritish journal of cancer1994
Polymerase chain reaction allelotyping of human ovarian cancer.
Article in British journal of cancer, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- Systematic review and meta-analysis of ovarian cancers: estimation of microsatellite-high frequency and characterization of mismatch repair deficient tumor histology.Clinical cancer research : an official journal of the American Association for Cancer Research · 2008Pooled it
- Review
- Article
- Frizzled homolog proteins, microRNAs and Wnt signaling in cancer.International journal of cancer · 2013Review
- Inactivation of X-linked tumor suppressor genes in human cancer.Future oncology (London, England) · 2012Review
- FOXP3 as an X-linked tumor suppressor.Discovery medicine · 2010Review
- An allelotype analysis indicating the presence of two distinct ovarian clear-cell carcinogenic pathways: endometriosis-associated pathway vs. clear-cell adenofibroma-associated pathway.Virchows Archiv : an international journal of pathology · 2009Article
- Hereditary ovarian carcinoma: heterogeneity, molecular genetics, pathology, and management.Molecular oncology · 2009Review
- Yin yang 1 modulates taxane response in epithelial ovarian cancer.Molecular cancer research : MCR · 2009Article
- Review
- Allelotype analysis of common epithelial ovarian cancers with special reference to comparison between clear cell adenocarcinoma with other histological types.Japanese journal of cancer research : Gann · 2002Article
- Loss of heterozygosity in the Hodgkin-Reed Sternberg cell line L1236.British journal of cancer · 2001Article
- Ovarian cancer cells that coexpress endogenous Rb and p16 are insensitive to overexpression of functional p16 protein.Oncogene · 2000Article
- Molecular detection of tumour DNA in serum and peritoneal fluid from ovarian cancer patients.British journal of cancer · 1999Article
- Allele loss and mutation screen at the Peutz-Jeghers (LKB1) locus (19p13.3) in sporadic ovarian tumours.British journal of cancer · 1999Article
- Evaluation of FHIT gene alterations in ovarian cancer.British journal of cancer · 1998Article
- Loss of heterozygosity at the 5,10-methylenetetrahydrofolate reductase locus in human ovarian carcinomas.British journal of cancer · 1997Article
- High frequency of chromosome 9 deletion in ovarian cancer: evidence for three tumour-suppressor loci.British journal of cancer · 1996Article
- Molecular genetic evidence for unifocal origin of advanced epithelial ovarian cancer and for minor clonal divergence.British journal of cancer · 1995Article
- The genetic analysis of ovarian cancer.British journal of cancer · 1995Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have used a set of microsatellite polymorphisms (MSPs) to examine the location and frequency of allele loss throughout the genome in a panel of 25 human epithelial ovarian tumours. When more than one MSP was employed per arm, mean informativity was 85.2% (range 64-100%). The average fractional allelic loss was 0.28 (range 0-0.65). A high frequency of allele loss was seen at 5q (40%), 9q (48%), 11p (43%), 14q (46%), 15q (40%), 17p (61%), 17q (64%), 19p (45%) and Xp (40%), confirming previous findings at some sites, but also suggesting the existence of new tumour-suppressor genes in regions (9q, 14q, 15q) which have not previously been studied in ovarian cancer. For 9q and 14q, partial loss of the arm was more common than loss of heterozygosity for all loci. There was a significant relationship between allele loss affecting the short arm of chromosome 17 and allele loss affecting 17q (P < 0.001). No other relationship was detected between allele losses at different sites. Polymerase chain reaction allelotyping is suitable for the examination of very small tumour samples and tumours in which classical karyotyping is problematic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.