ReviewClinical microbiology reviews1994
Adhesins and ligands involved in the interaction of Candida spp. with epithelial and endothelial surfaces.
Review in Clinical microbiology reviews, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 208 citations in OpenAlex.
- Review
- Revisiting the History of Candidiasis.Cureus · 2025Review
- Functional annotation of Candida albicans hypothetical proteins: a bioinformatics approach.Archives of microbiology · 2024Article
- Filament Negative RegulatorJournal of fungi (Basel, Switzerland) · 2022Article
- The Promiscuous Profile of Complement Receptor 3 in Ligand Binding, Immune Modulation, and Pathophysiology.Frontiers in immunology · 2021Review
- A new perspective in sepsis treatment: could RGD-dependent integrins be novel targets?Drug discovery today · 2020Review
- Identification of Key Candidate Genes and Pathways ofIndian journal of microbiology · 2020Article
- Remusatia vivipara lectin and Sclerotium rolfsii lectin interfere with the development and gall formation activity of Meloidogyne incognita in transgenic tomato.Transgenic research · 2019Article
- An overview of lectin-glycan interactions: a key event in initiating fungal infection and pathogenesis.Archives of microbiology · 2018Review
- A multigene family encoding surface glycoproteins inMicrobial cell (Graz, Austria) · 2017Article
- Draft genome of a commonly misdiagnosed multidrug resistant pathogen Candida auris.BMC genomics · 2015Article
- Determination of MICING: a new assay for assessing minimal inhibitory concentration for invasive growth.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015Article
- Candida albicans-epithelial interactions and pathogenicity mechanisms: scratching the surface.Virulence · 2015Review
- Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia.Nature communications · 2014Article
- Interactions of Candida albicans with host epithelial surfaces.Journal of oral microbiology · 2013Review
- Candida albicans: A Model Organism for Studying Fungal Pathogens.ISRN microbiology · 2012Article
- Development of a novel ex vivo model of corneal fungal adherence.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2011Article
- Limited role of secreted aspartyl proteinases Sap1 to Sap6 in Candida albicans virulence and host immune response in murine hematogenously disseminated candidiasis.Infection and immunity · 2010Article
- Candida albicans-endothelial cell interactions: a key step in the pathogenesis of systemic candidiasis.Infection and immunity · 2008Review
- Systematic survey of nonspecific agglutination by Candida spp. in latex assays.Journal of clinical microbiology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adhesion of candidal species to the epithelium of the gastrointestinal or genitourinary tract stands as a critical first step in the pathogenesis of candidal infection. After colonization and replication at mucosal surfaces, Candida albicans and other pathogenic species may penetrate the mucosal barrier, enter the vascular tree, and disseminate hematogenously. The consequences of this pathogenic cascade evoke considerable morbidity and mortality, especially among immunocompromised patients. Thus, interactions of C. albicans and other candidal species with epithelium and endothelium may lead to serious consequences for the human host. This review evaluates candidate candidal adhesions for epithelial and endothelial surfaces, with emphasis on the specificity of the interaction, the inhibitors that have been employed, and the ligands that have been identified on mammalian cells or matrices. Three types of interactions are described: protein-protein interactions, lectin-like interactions, and incompletely defined interactions in which the adhesive ligand is as yet unidentified. Special attention is given to the roles of integrin-like proteins. Differences in the mechanisms of candidal attachment to epithelium and endothelium are delineated. Last, on the basis of the available literature, avenues of potentially fruitful investigation are proposed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.