ArticleMammalian genome : official journal of the International Mammalian Genome Society1993
In situ analysis of centromere segregation in C57BL/6 x Mus spretus interspecific backcrosses.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Mitotic Antipairing of Homologous Chromosomes.Results and problems in cell differentiation · 2022Article
- Live visualization of chromatin dynamics with fluorescent TALEs.Nature structural & molecular biology · 2013Article
- A genomic clone containing a telomere array maps near the centromere of mouse chromosome 6.Mammalian genome : official journal of the International Mammalian Genome Society · 1995Article
- A genetic linkage map of the mouse using restriction landmark genomic scanning (RLGS).Genetics · 1994Article
- Forward and reverse genetic approaches to behavior in the mouse.Science (New York, N.Y.) · 1994Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The analysis of major satellite sequence differences between Mus spretus and laboratory mice provides a robust method for analyzing the centromere location for the genetic maps of each mouse chromosome. Fluorescence in situ hybridization (FISH) of a genomic probe, pMR196, for the laboratory mouse major satellite sequences was used to identify C57BL/6Ros (B6) pericentromeric heterochromatin in progeny of reciprocal backcross matings. These included 80 (B6 x M. spretus)F1 x M. spretus progeny (BSS) and 70 (B6 x M. spretus)F1 x B6 (BSB) progeny. FISH analysis of pericentromeric heterochromatin was conducted on the same metaphase spreads that were karyotypically analyzed for chromosome-specific banding patterns. Analysis of chromosomal segregation suggested that there was not primary deviation from random assortment during meiosis in the interspecific hybrid female, because nearly all of the 190 pair-wise comparisons did not deviate from expected and because there was no consistent pattern of deviation of the same chromosomes in the reciprocal backcross progeny from similar (C57BL/6 x M. spretus)F1 hybrid females. These results affirm the value of using the major satellite to genetically mark pericentromeric heterochromatin in the analysis of the segregation and assortment of centromeres in Mus interspecific crosses.
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