ArticleBasic research in cardiology
The effects of lactic acid production on contraction and intracellular pH during hypoxia in cardiac muscle.
Article in Basic research in cardiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 9 citations in OpenAlex.
- Acute Cardiomyopathy and Delayed Neuropsychiatric Sequelae of Carbon Monoxide Poisoning: A Case Report.Cureus · 2023Article
- Article
- Infection with AV-SUR2A protects H9C2 cells against metabolic stress: a mechanism of SUR2A-mediated cytoprotection independent from the K(ATP) channel activity.Biochimica et biophysica acta · 2010Article
- The effect of metabolic inhibition on rat uterine intracellular pH and its role in contractile failure.Pflugers Archiv : European journal of physiology · 1995Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
During hypoxia cardiac contraction declines and there is an intracellular acidosis. We find that, if this acidosis is abolished by decreasing pCO2 there is little restoration of force. Therefore the acidosis is not the major cause of the decline of force. The acidosis may partly result from the generation of lactic acid. No acidosis, is however, seen in isolated cardiac cells. Furthermore a theoretical model shows that lactic acid production would be expected to produce a transient acidosis. We suggest that the observed maintained acidosis may be a consequence of extracellular lactic acid accumulation affecting intracellular pH.
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