ArticleMolecular and cellular biology1994
Human GATA-3 trans-activation, DNA-binding, and nuclear localization activities are organized into distinct structural domains.
Article in Molecular and cellular biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
44 citing papers in PubMed, 114 citations in OpenAlex.
- Article
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- Role of the pioneer transcription factor GATA2 in health and disease.Journal of molecular medicine (Berlin, Germany) · 2023Review
- CRISPR/Cas9 screen uncovers functional translation of cryptic lncRNA-encoded open reading frames in human cancer.The Journal of clinical investigation · 2023Article
- Evolutionary Dynamics of the SKN-1 → MED → END-1,3 Regulatory Gene Cascade inG3 (Bethesda, Md.) · 2020Article
- GATA3 Truncating Mutations Promote Cistromic Re-Programming In Vitro, but Not Mammary Tumor Formation in Mice.Journal of mammary gland biology and neoplasia · 2019Article
- HDR syndrome with a novel mutation in GATA3 mimicking a congenital X-linked stapes gusher: a case report.BMC medical genetics · 2017Article
- GATA3 Abundance Is a Critical Determinant of T Cell Receptor β Allelic Exclusion.Molecular and cellular biology · 2017Article
- Unusual Proliferative Glomerulonephritis in a Patient Diagnosed to Have Hypoparathyroidism, Sensorineural Deafness, and Renal Dysplasia (HDR) Syndrome with a Novel Mutation in the GATA3 Gene.Internal medicine (Tokyo, Japan) · 2017Article
- Gain- and Loss-of-Function Mutations in the Breast Cancer Gene GATA3 Result in Differential Drug Sensitivity.PLoS genetics · 2016Article
- GATA3-dependent cellular reprogramming requires activation-domain dependent recruitment of a chromatin remodeler.Genome biology · 2016Article
- A novel loss-of-function mutation of GATA3 (p.R299Q) in a Japanese family with Hypoparathyroidism, Deafness, and Renal Dysplasia (HDR) syndrome.BMC endocrine disorders · 2015Article
- Gata2b is a restricted early regulator of hemogenic endothelium in the zebrafish embryo.Development (Cambridge, England) · 2015Article
- Hypoparathyroidism, sensorineural deafness, and renal dysgenesis syndrome with a GATA3 mutation.Annals of pediatric endocrinology & metabolism · 2015Article
- GATA3 in Breast Cancer: Tumor Suppressor or Oncogene?Gene expression · 2015Review
- Decreased expression of the GATA3 gene is associated with poor prognosis in primary gastric adenocarcinoma.PloS one · 2014Article
- Importins and exportins regulating allergic immune responses.Mediators of inflammation · 2014Review
- Evaluation of ultra-deep targeted sequencing for personalized breast cancer care.Breast cancer research : BCR · 2013Article
- Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- GATA3 mutations found in breast cancers may be associated with aberrant nuclear localization, reduced transactivation and cell invasiveness.Hormones & cancer · 2013Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
GATA-3 is a zinc finger transcription factor which is expressed in a highly restricted and strongly conserved tissue distribution pattern in vertebrate organisms, specifically, in a subset of hematopoietic cells, in cells within the central and peripheral nervous systems, in the kidney, and in placental trophoblasts. Tissue-specific cellular genes regulated by GATA-3 have been identified in T lymphocytes and the placenta, while GATA-3-regulated genes in the nervous system and kidney have not yet been defined. We prepared monoclonal antibodies with which we could dissect the biochemical and functional properties of human GATA-3. The results of these experiments show some anticipated phenotypes, for example, the definition of discrete domains required for specific DNA-binding site recognition (amino acids 303 to 348) and trans activation (amino acids 30 to 74). The signaling sequence for nuclear localization of human GATA-3 is a property conferred by sequences within and surrounding the amino finger (amino acids 249 to 311) of the protein, thereby assigning a function to this domain and thus explaining the curious observation that this zinc finger is dispensable for DNA binding by the GATA family of transcription factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.