ArticleJournal of molecular evolution1993
Evolutionary study of multigenic families mapping close to the human MHC class I region.
Article in Journal of molecular evolution, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 121 citations in OpenAlex.
- Identification of the Fc-alpha/mu receptor in Xenopus provides insight into the emergence of the poly-Ig receptor (pIgR) and mucosal Ig transport.European journal of immunology · 2021Article
- TRIM22. A Multitasking Antiviral Factor.Cells · 2021Review
- Resveratrol reduced the detrimental effects of malondialdehyde on human endothelial cells.Journal of cardiovascular and thoracic research · 2021Article
- SPRYSEC Effectors: A Versatile Protein-Binding Platform to Disrupt Plant Innate Immunity.Frontiers in plant science · 2016Review
- Crystal structure of the TRIM25 B30.2 (PRYSPRY) domain: a key component of antiviral signalling.The Biochemical journal · 2013Article
- Butyrophilin Btn2a2 inhibits TCR activation and phosphatidylinositol 3-kinase/Akt pathway signaling and induces Foxp3 expression in T lymphocytes.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Structure and function of the SPRY/B30.2 domain proteins involved in innate immunity.Protein science : a publication of the Protein Society · 2013Review
- Milk lipid secretion: recent biomolecular aspects.Biomolecular concepts · 2012Article
- Determinants of adipophilin function in milk lipid formation and secretion.Trends in endocrinology and metabolism: TEM · 2011Review
- Scianna: the lucky 13th blood group system.Immunohematology · 2011Review
- Molecular characterization and expression pattern of tripartite motif protein 39 in Gallus gallus with a complete PRY/SPRY domain.International journal of molecular sciences · 2011Article
- Gatekeepers of intestinal inflammation.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2010Review
- The PRY/SPRY/B30.2 domain of butyrophilin 1A1 (BTN1A1) binds to xanthine oxidoreductase: implications for the function of BTN1A1 in the mammary gland and other tissues.The Journal of biological chemistry · 2009Article
- Yin-Yang of costimulation: crucial controls of immune tolerance and function.Immunological reviews · 2009Review
- Ear1p and Ssh4p are new adaptors of the ubiquitin ligase Rsp5p for cargo ubiquitylation and sorting at multivesicular bodies.Molecular biology of the cell · 2008Article
- The retroviral restriction factor TRIM5alpha.Current infectious disease reports · 2007Article
- Structural and functional insights into the B30.2/SPRY domain.The EMBO journal · 2006Article
- Characterisation of a cluster of TRIM-B30.2 genes in the chicken MHC B locus.Immunogenetics · 2005Article
- 2004 Nomenclature for the chicken major histocompatibility (B and Y) complex.Immunogenetics · 2004Review
- Familial Mediterranean fever.Pediatric nephrology (Berlin, Germany) · 2003Review
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During a search for novel coding sequences within the human MHC class I region (chromosome 6p21.3), we found an exon (named B30-2) coding for a 166-amino-acid peptide which is very similar to the C-terminal domain of several coding sequences: human 52-kD Sjögren's syndrome nuclear antigen A/Ro (SS-A/Ro) and ret finger protein (RFP), Xenopus nuclear factor 7 (XNF7), and bovine butyrophilin. The first three of these proteins share similarities over the whole length of the molecule whereas butyrophilin is similar in the C-terminal domain. The N-terminal domain of butyrophilin is similar to rat myelin/oligodendrocyte glycoprotein (MOG) and chicken B blood group system (B-G) protein. These domains are components of a new subfamily of the immunoglobulin superfamily (IgSF). Butyrophilin is thus a mosaic protein composed of the MOG/B-G Ig-like domain and the C-terminal domain of 52-kD SS-A/Ro, RFP, and XNF7 (B30-2-like domain). Moreover, in situ hybridization shows that RFP, butyrophilin, and MOG map to the human chromosome 6p21.3-6p22 region and are thus close to the MHC class I genes. It is therefore possible that the butyrophilin gene is the product of an exon shuffling event which occurred between ancestors of the RFP and MOG genes. To our knowledge, this is the first example of the colocalization of a chimeric gene and its putative progenitors. Finally, regulatory protein T-lymphocyte 1 (Rpt-1) shares similarities with the N-terminal halves of RFP, 52-kD SS-A/Ro, and XNF7, but not with the B30-2-like domain. We show that the ancestral Rpt-1 gene evolved by overprinting.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.