ArticleThe EMBO journal1994
HPV16 E7 oncoprotein deregulates B-myb expression: correlation with targeting of p107/E2F complexes.
Article in The EMBO journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 123 citations in OpenAlex.
- Comparative Analysis of Transcription Factor Binding Sites in the Long Control Region Across Human Papillomavirus Types.Viruses · 2026Article
- HPV16 E7 Nucleotide Variants Found in Cancer-Free Subjects Affect E7 Protein Expression and Transformation.Cancers · 2022Article
- MPS1 is involved in the HPV16-E7-mediated centrosomes amplification.Cell division · 2021Article
- MYBL2 (B-Myb): a central regulator of cell proliferation, cell survival and differentiation involved in tumorigenesis.Cell death & disease · 2017Review
- The human papillomavirus E7 oncoprotein as a regulator of transcription.Virus research · 2017Review
- Role of WDHD1 in Human Papillomavirus-Mediated Oncogenesis Identified by Transcriptional Profiling of E7-Expressing Cells.Journal of virology · 2016Article
- The association of mammalian DREAM complex and HPV16 E7 proteins.American journal of cancer research · 2015Review
- Role of Cdk1 in DNA damage-induced G1 checkpoint abrogation by the human papillomavirus E7 oncogene.Cell cycle (Georgetown, Tex.) · 2014Article
- The papillomavirus E7 proteins.Virology · 2013Review
- Molecular Signature of HPV-Induced Carcinogenesis: pRb, p53 and Gene Expression Profiling.Current genomics · 2009Article
- Critical roles for non-pRb targets of human papillomavirus type 16 E7 in cervical carcinogenesis.Cancer research · 2006Article
- Examination of the pRb-dependent and pRb-independent functions of E7 in vivo.Journal of virology · 2005Article
- Recapitulation of the effects of the human papillomavirus type 16 E7 oncogene on mouse epithelium by somatic Rb deletion and detection of pRb-independent effects of E7 in vivo.Molecular and cellular biology · 2003Article
- Transglutaminase 2 inhibits Rb binding of human papillomavirus E7 by incorporating polyamine.The EMBO journal · 2003Article
- B-Myb overcomes a p107-mediated cell proliferation block by interacting with an N-terminal domain of p107.Oncogene · 2002Article
- E7 proteins from oncogenic human papillomavirus types transactivate p73: role in cervical intraepithelial neoplasia.British journal of cancer · 2002Article
- p73 is over-expressed in vulval cancer principally as the Delta 2 isoform.British journal of cancer · 2001Article
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Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
HPV16 is a human tumour virus encoding two principal oncoproteins, E6 and E7. Expression of E7 can induce DNA synthesis in quiescent cells and this property coincides with its ability to bind to the cell proteins pRb and p107. As these cell proteins are regulators of the transcription factor E2F, we have investigated whether the interaction with E7 could result in induction of cell cycle regulated genes. We show that B-myb, whose induction at the G1/S boundary is regulated by release from E2F mediated transcriptional repression, is a target for transcriptional activation by E7 and is the first E7 responsive cell gene to be identified. E7 transactivation leads to both inappropriate transcription of B-myb during G1 and constitutive over-expression in cycling cells. B-Myb plays an essential role in cell cycle progression, and activation by E7 is likely to contribute to the mitogenic activity of the viral oncoprotein. Regulation of the B-myb promoter in NIH3T3 cells correlates with binding of distinct p107-containing complexes at the E2F binding site, and analysis of E7 mutants confirms that B-myb transcription in these cells is regulated through interactions with p107 rather than pRb. These results provide the first example of a potentially specific role for p107 in the regulation of the cell cycle.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.