ArticleThe EMBO journal1994
A selective defect in IgM antigen receptor synthesis and transport causes loss of cell surface IgM expression on tolerant B lymphocytes.
Article in The EMBO journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 72 citations in OpenAlex.
- Homeostatic role of B-1 cells in tissue immunity.Frontiers in immunology · 2023Review
- Human B-cell subset identification and changes in inflammatory diseases.Clinical and experimental immunology · 2022Review
- Mechanism of CD79A and CD79B Support for IgM+ B Cell Fitness through B Cell Receptor Surface Expression.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- MYD88Therapeutic advances in hematology · 2022Review
- Human marginal zone B cell development from early T2 progenitors.The Journal of experimental medicine · 2021Article
- The enigmatic function of IgD: some answers at last.European journal of immunology · 2018Review
- Synergistic cooperation and crosstalk betweenThe Journal of experimental medicine · 2017Article
- IgD attenuates the IgM-induced anergy response in transitional and mature B cells.Nature communications · 2016Article
- NFATc2 (NFAT1) assists BCR-mediated anergy in anti-insulin B cells.Molecular immunology · 2014Article
- Anergic responses characterize a large fraction of human autoreactive naive B cells expressing low levels of surface IgM.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- The double life of a B-1 cell: self-reactivity selects for protective effector functions.Nature reviews. Immunology · 2011Review
- B cells and transplantation tolerance.Nature reviews. Nephrology · 2010Review
- Essential role of membrane cholesterol in accelerated BCR internalization and uncoupling from NF-kappa B in B cell clonal anergy.The Journal of experimental medicine · 2006Article
- High Mda-7 expression promotes malignant cell survival and p38 MAP kinase activation in chronic lymphocytic leukemia.Leukemia · 2006Article
- Epstein-Barr virus LMP2A alters in vivo and in vitro models of B-cell anergy, but not deletion, in response to autoantigen.Journal of virology · 2005Article
- Selection of B lymphocytes in the periphery is determined by the functional capacity of the B cell antigen receptor.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Article
- Entry of B cell receptor into signaling domains is inhibited in tolerant B cells.The Journal of experimental medicine · 2000Article
- Role of Syk in B-cell development and antigen-receptor signaling.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- A disease-related rheumatoid factor autoantibody is not tolerized in a normal mouse: implications for the origins of autoantibodies in autoimmune disease.The Journal of experimental medicine · 1996Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To explore the biochemical basis for maintaining immunological tolerance by functional inactivation of self-reactive B lymphocytes, transgenic mice carrying rearranged anti-lysozyme immunoglobulin transgenes and a lysozyme transgene were used as a source of large numbers of tolerant self-reactive B cells. Antigen receptors of the IgD isotype were expressed at normal levels on tolerant B cells, contained the heterodimeric MB1/B29 signalling component of the receptor complex and were structurally indistinguishable from IgD on nontolerant B cells. In contrast, cell surface expression of IgM receptor complexes on tolerant B cells was greatly reduced, despite normal expression of mRNA encoding the receptor components. Three-fold fewer immunoreactive mu heavy chains were detectable after a short period of biosynthetic labelling and the immunoreactive mu chains produced were paired with kappa light chains and assembled normally into intact receptor complexes containing the MB1/B29 heterodimer. Nascent IgM receptor complexes nevertheless failed to be processed into an endoglycosidase H-resistant form in the tolerant B cells and thus appeared to be selectively blocked in their transport from the endoplasmic reticulum to the medial Golgi. These findings demonstrate that intracellular trafficking of antigen receptor complexes is regulated by exposure to receptor stimuli at the cell surface causing a long-lasting decrease in surface receptor expression on tolerant B cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.