ArticleCellular and molecular neurobiology1993
Steroid-induced inhibition of adenosine transport in cultured chromaffin cells.
Article in Cellular and molecular neurobiology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 13 citations in OpenAlex.
- Nucleoside anticancer drugs: the role of nucleoside transporters in resistance to cancer chemotherapy.Oncogene · 2003Review
- Prolactin and cyclosporine modulate adenosine transporters and adenosine A1 receptors in the rat brain.Journal of physiology and biochemistry · 2000Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
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Abstract
1. Adenosine transport is subjected to regulation by hormones. Glucocorticoids, sexual steroids, and retinoic acid inhibit adenosine transport in chromaffin cells after a long-term incubation period (24 hr). No effects were observed after a short-term incubation period (10 min). 2. The kinetic parameters of transporters were studied. No significant changes were observed for the affinity constant (Km), whose value remains at 1 +/- 0.2 microM after 24-hr incubation in the presence of these compounds. The maximal velocity (Vmax) was significantly modified, with a decrease of about 20% in all cases. 3. NBTI binding was not modified in its affinity constant or maximal bound capacity (Bmax) by the presence of these compounds for a 24-hr incubation period. Thus the efficiency of transporters (quotient Vmax/Bmax) changed from 10.9 +/- 0.08 adenosine molecules transported per transporter per sec in the control cells to 9.1 +/- 0.07 in hormone-treated cultured cells. 4. The thyroid hormone (T3) significantly increased adenosine transport in a long-term incubation period in chromaffin cells (24 hr). This activatory effect is antagonized by steroid hormones and retinoic acid.
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