ArticleProceedings of the National Academy of Sciences of the United States of America1994
Dynamic actin structures stabilized by profilin.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 124 citations in OpenAlex.
- Redox and actin, a fascinating story.Redox biology · 2025Review
- Functional Characterization of anMolecules (Basel, Switzerland) · 2022Article
- The role of profilin-1 in cardiovascular diseases.Journal of cell science · 2021Review
- Disruption of profilin1 function suppresses developmental and pathological retinal neovascularization.The Journal of biological chemistry · 2020Article
- The Actin Cytoskeleton in Myelinating Cells.Neurochemical research · 2020Review
- Structure-based virtual screening identifies a small-molecule inhibitor of the profilin 1-actin interaction.The Journal of biological chemistry · 2018Article
- The effect of piperlongumine on endothelial and lung adenocarcinoma cells with regulated expression of profilin-1.OncoTargets and therapy · 2018Article
- Hydrogen sulfide modulates actin-dependent auxin transport via regulating ABPs results in changing of root development in Arabidopsis.Scientific reports · 2015Article
- Profilin-1 serves as a gatekeeper for actin assembly by Arp2/3-dependent and -independent pathways.Developmental cell · 2015Article
- Structural basis of thymosin-β4/profilin exchange leading to actin filament polymerization.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Article
- Overexpression of profilin 3 affects cell elongation and F-actin organization in Arabidopsis thaliana.Plant cell reports · 2013Article
- Profilin1 facilitates staurosporine-triggered apoptosis by stabilizing the integrin β1-actin complex in breast cancer cells.Journal of cellular and molecular medicine · 2012Article
- Epithelial microfilament regulators show regional distribution in mouse conjunctiva.Molecular vision · 2010Article
- Fine-tuning of neuronal architecture requires two profilin isoforms.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Accelerators, Brakes, and Gears of Actin Dynamics in Dendritic Spines.The open neuroscience journal · 2009Article
- iPLA2beta: front and center in human monocyte chemotaxis to MCP-1.The Journal of experimental medicine · 2008Article
- Profilin-1 is a negative regulator of mammary carcinoma aggressiveness.British journal of cancer · 2007Article
- The subcellular organization of cortactin in hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- A balance of capping protein and profilin functions is required to regulate actin polymerization in Drosophila bristle.Molecular biology of the cell · 2003Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
We describe the production and analysis of clonal cell lines in which we have overexpressed human profilin, a small ubiquitous actin monomer binding protein, to assess the role of profilin on actin function in vivo. The concentration of filamentous actin is increased in cells with higher profilin levels, and actin filament half-life measured in these cells is directly proportional to the steady-state profilin concentration. The distribution of actin filaments is altered by profilin overexpression. While parallel actin bundles crossing the cells are virtually absent in cells overexpressing profilin, the submembranous actin network of these cells is denser than in control cells. These results suggest that in vivo profilin regulates the stability, and thereby distribution, of specific dynamic actin structures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.