ArticleProceedings of the National Academy of Sciences of the United States of America1994
Nuclear-mitotic apparatus protein: a structural protein interface between the nucleoskeleton and RNA splicing.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 82 citations in OpenAlex.
- Immune complexome analysis reveals the presence of immune complexes and identifies disease-specific immune complex antigens in saliva samples from patients with Sjögren's syndrome.Clinical and experimental immunology · 2021Article
- The RanGTP Pathway: From Nucleo-Cytoplasmic Transport to Spindle Assembly and Beyond.Frontiers in cell and developmental biology · 2015Review
- KSHV LANA--the master regulator of KSHV latency.Viruses · 2014Review
- Sam68 regulates a set of alternatively spliced exons during neurogenesis.Molecular and cellular biology · 2009Article
- Kaposi's sarcoma-associated herpesvirus-encoded LANA can interact with the nuclear mitotic apparatus protein to regulate genome maintenance and segregation.Journal of virology · 2008Article
- NuMA influences higher order chromatin organization in human mammary epithelium.Molecular biology of the cell · 2007Article
- Autoantibodies to mitotic apparatus: association with other autoantibodies and their clinical significance.Journal of clinical immunology · 2006Article
- Association of the NuMA region on chromosome 11q13 with breast cancer susceptibility.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Association of the 72/74-kDa proteins, members of the heterogeneous nuclear ribonucleoprotein M group, with the pre-mRNA at early stages of spliceosome assembly.The Biochemical journal · 2002Article
- The 72/74-kDa polypeptides of the 70-110 S large heterogeneous nuclear ribonucleoprotein complex (LH-nRNP) represent a discrete subset of the hnRNP M protein family.The Biochemical journal · 2000Article
- Autoantibodies to components of the mitotic apparatus.Molecular biology reports · 1998Review
- Molecular definition of heterogeneous nuclear ribonucleoprotein R (hnRNP R) using autoimmune antibody: immunological relationship with hnRNP P.Nucleic acids research · 1998Article
- Splicing factors associate with hyperphosphorylated RNA polymerase II in the absence of pre-mRNA.The Journal of cell biology · 1997Article
- A connection between pre-mRNA splicing and the cell cycle in fission yeast: cdc28+ is allelic with prp8+ and encodes an RNA-dependent ATPase/helicase.Molecular biology of the cell · 1996Article
- The human hnRNP-M proteins: structure and relation with early heat shock-induced splicing arrest and chromosome mapping.Nucleic acids research · 1996Article
- The herpes simplex virus type 1 regulatory protein ICP27 coimmunoprecipitates with anti-Sm antiserum, and the C terminus appears to be required for this interaction.Journal of virology · 1996Article
- An amino acid sequence motif sufficient for subnuclear localization of an arginine/serine-rich splicing factor.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- The nuclear matrix phosphoprotein p255 associates with splicing complexes as part of the [U4/U6.U5] tri-snRNP particle.Nucleic acids research · 1995Article
- RNA polymerase II transcription and the functional organization of the mammalian cell nucleus.Chromosoma · 1995Review
- Association of nuclear matrix antigens with exon-containing splicing complexes.The Journal of cell biology · 1994Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Vertebrate splicing factors are localized to discrete domains within the nuclei of somatic cells. The mechanism whereby such nuclear domains, identified as speckles by immunofluorescence microscopy, are generated is unclear. Recent studies suggest that the spatial order within the nucleus is maintained by nuclear matrix factors. Here we show that a protein in the nuclear matrix and mitotic apparatus [nuclear-mitotic apparatus protein, NuMA; Lydersen, B. & Pettijohn, D. (1980) Cell 22, 489-499] colocalizes with splicing factors in interphase nuclei and is associated with small nuclear ribonucleoproteins in a complex immunoprecipitated from HeLa extract with small nuclear ribonucleoprotein antibodies. Moreover, NuMA associates with splicing complexes that are reconstituted in vitro using wild-type pre-mRNA, but not with nonspecific RNA. Cumulatively, these observations suggest a function of NuMA or NuMA-like proteins in interphase cells in providing a bridge between RNA processing and the nucleoskeleton.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.