ArticleJournal of virology1994
pet, a small sequence distal to the pregenome cap site, is required for expression of the duck hepatitis B virus pregenome.
Article in Journal of virology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Lost Small Envelope Protein Expression from Naturally Occurring PreS1 Deletion Mutants of Hepatitis B Virus Is Often Accompanied by Increased HBx and Core Protein Expression as Well as Genome Replication.Journal of virology · 2021Article
- Functional characterization of hepatitis B virus core promoter mutants revealed transcriptional interference among co-terminal viral mRNAs.The Journal of general virology · 2016Article
- Characterization of nucleosome positioning in hepadnaviral covalently closed circular DNA minichromosomes.Journal of virology · 2012Article
- A high level of mutation tolerance in the multifunctional sequence encoding the RNA encapsidation signal of an avian hepatitis B virus and slow evolution rate revealed by in vivo infection.Journal of virology · 2011Article
- Drastic reduction in the production of subviral particles does not impair hepatitis B virus virion secretion.Journal of virology · 2009Article
- A secondary structure that contains the 5' and 3' splice sites suppresses splicing of duck hepatitis B virus pregenomic RNA.Journal of virology · 2002Article
- Hepatitis B virus biology.Microbiology and molecular biology reviews : MMBR · 2000Review
- Interferon gene transfer by a hepatitis B virus vector efficiently suppresses wild-type virus infection.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Infection of ducklings with virus particles containing linear double-stranded duck hepatitis B virus DNA: illegitimate replication and reversion.Journal of virology · 1998Article
- A novel transcriptional element in circular DNA monomers of the duck hepatitis B virus.Journal of virology · 1997Article
- cis-Acting sequences in addition to donor and acceptor sites are required for template switching during synthesis of plus-strand DNA for duck hepatitis B virus.Journal of virology · 1997Article
- A functional hepatocyte nuclear factor 3 binding site is a critical component of the duck hepatitis B virus major surface antigen promoter.Journal of virology · 1996Article
- A splice hepadnavirus RNA that is essential for virus replication.The EMBO journal · 1996Article
- Illegitimate replication of linear hepadnavirus DNA through nonhomologous recombination.Journal of virology · 1995Article
- Evidence that hepatocyte turnover is required for rapid clearance of duck hepatitis B virus during antiviral therapy of chronically infected ducks.Journal of virology · 1994Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We have found that transcription of the pregenome of an avian hepadnavirus, duck hepatitis B virus (DHBV), is dependent on the presence of a small element in the 5' transcribed region of the pregenome-encoding sequence. This element, which we have named pet (positive effector of transcription), exerts its effect in cis in a position and orientation-dependent manner, suggesting that it may function as part of the nascent pregenome transcript. The requirement for pet depends on the presence in the transcription unit of a region of the DHBV genome located upstream of the envelope promoters, which specifically suppresses transcription of templates lacking pet. In the presence of this region, deletion of pet activates transcription from downstream promoters, suggesting that pregenome transcription complexes fail to reach the downstream promoters. In vitro transcription experiments support the model that pet is required for transcription elongation on the DHBV template. We speculate that pet is required to suppress transcription termination during the first passage of pregenome transcription complexes through a viral termination region on the circular viral DNA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.