ArticleJournal of virology1994
Subcellular distribution of human immunodeficiency virus type 1 Rev and colocalization of Rev with RNA splicing factors in a speckled pattern in the nucleoplasm.
Article in Journal of virology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 53 citations in OpenAlex.
- Structure, Activity and Function of the Protein Arginine Methyltransferase 6.Life (Basel, Switzerland) · 2021Review
- Proteolytic activity assayed by subcellular localization switching of a substrate.Biochemistry and biophysics reports · 2016Article
- Dynamics of the human and viral m(6)A RNA methylomes during HIV-1 infection of T cells.Nature microbiology · 2016Article
- Nuclear trafficking of retroviral RNAs and Gag proteins during late steps of replication.Viruses · 2013Review
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- PRMT6 diminishes HIV-1 Rev binding to and export of viral RNA.Retrovirology · 2006Article
- HIV-1 Rev oligomerization is not obligatory in the presence of an extra basic domain.Retrovirology · 2005Article
- Mutational analysis of bovine leukemia virus Rex: identification of a dominant-negative inhibitor.Journal of virology · 2005Article
- Identification of a domain in human immunodeficiency virus type 1 rev that is required for functional activity and modulates association with subnuclear compartments containing splicing factor SC35.Journal of virology · 2000Article
- Marek's disease herpesvirus transforming protein MEQ: a c-Jun analogue with an alternative life style.Virus genes · 2000Review
- Mta has properties of an RNA export protein and increases cytoplasmic accumulation of Epstein-Barr virus replication gene mRNA.Journal of virology · 1998Article
- Nucleolar and nuclear localization properties of a herpesvirus bZIP oncoprotein, MEQ.Journal of virology · 1997Article
- A suboptimal 5' splice site is a cis-acting determinant of nuclear export of polyomavirus late mRNAs.Molecular and cellular biology · 1996Article
- Localization of HIV-1 RNA in mammalian nuclei.The Journal of cell biology · 1996Article
- cis-acting elements in human immunodeficiency virus type 1 RNAs direct viral transcripts to distinct intranuclear locations.Journal of virology · 1996Article
- Circulating human dendritic cells differentially express high levels of a 55-kd actin-bundling protein.The American journal of pathology · 1996Article
- Nuclear export of the human immunodeficiency virus type 1 nucleocytoplasmic shuttle protein Rev is mediated by its activation domain and is blocked by transdominant negative mutants.Journal of virology · 1995Article
- The human immunodeficiency virus type 1 Rev protein and the Rev-responsive element counteract the effect of an inhibitory 5' splice site in a 3' untranslated region.Molecular and cellular biology · 1995Article
- The human immunodeficiency virus type 1 Rev protein shuttles between the cytoplasm and nuclear compartments.Molecular and cellular biology · 1994Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human immunodeficiency virus type 1 (HIV-1) Rev (regulator of virion protein expression) protein exemplifies a new type of posttranscriptional regulation. One main function of Rev is to increase the cytoplasmic expression of unspliced and incompletely spliced retroviral mRNAs from which viral structural proteins are made. In that way, Rev is essential in order to complete the retroviral life cycle. The biology of Rev in the host cell has remained elusive. In this study, a complex distribution of Rev in single cells was found. Rev was found in the cytoplasm, in a perinuclear zone, in the nucleoplasm, and in the nucleoli. In the nucleoplasm, Rev colocalized in a speckled pattern with host cell factors known to assemble on nascent transcripts. Those factors are involved in the processing of heterogeneous RNA to spliced mRNA in the nucleoplasm of all cells. The distribution of Rev was dependent only on Rev and host cell interactions, since neither the Rev target RNA nor other HIV proteins were expressed in the cells. Rev was found in the same subcellular compartments of cells treated for extended periods with cycloheximide, an inhibitor of protein synthesis. This finding implies that Rev shuttles continuously between cytoplasmic and nucleoplasmic compartments. The results suggest a potential role for Rev both in the RNA-splicing process and in the nucleocytoplasmic transport of Rev-dependent HIV mRNA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.