ArticleAmerican journal of human genetics1993
Association of transforming growth-factor alpha gene polymorphisms with nonsyndromic cleft palate only (CPO).
Article in American journal of human genetics, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Growth factor analysis in children with non-syndromic orofacial clefts: a systematic review.BMC oral health · 2026Pooled it
- Association between polymorphism of TGFA Taq I and cleft lip and/or palate: a meta-analysis.BMC oral health · 2014Pooled it
- Environmental mechanisms of orofacial clefts.Birth defects research · 2020Review
- Current Controversies in Diagnosis and Management of Cleft Palate and Velopharyngeal Insufficiency.BioMed research international · 2015Review
- GFA Taq I polymorphism and cleft lip with or without cleft palate (CL/P) risk.International journal of clinical and experimental medicine · 2015Article
- TGFA and IRF6 contribute to the risk of nonsyndromic cleft lip with or without cleft palate in northeast China.PloS one · 2013Article
- Genetics and management of the patient with orofacial cleft.Plastic surgery international · 2012Article
- Genetics of nonsyndromic orofacial clefts.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2012Review
- Prdm16 is required for normal palatogenesis in mice.Human molecular genetics · 2010Article
- Isolated cleft palate in mice with a targeted mutation of the LIM homeobox gene lhx8.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Association of MSX1 and TGFB3 with nonsyndromic clefting in humans.American journal of human genetics · 1998Article
- Prediction of liability to orofacial clefting using genetic and craniofacial data from parents.Journal of medical genetics · 1998Article
- Genome scan for teratogen-induced clefting susceptibility loci in the mouse: evidence of both allelic and locus heterogeneity distinguishing cleft lip and cleft palate.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Orofacial clefts, parental cigarette smoking, and transforming growth factor-alpha gene variants.American journal of human genetics · 1996Article
- Familial recurrence-pattern analysis of nonsyndromic isolated cleft palate--a Danish Registry study.American journal of human genetics · 1996Article
- Transforming growth factor-beta 3 is required for secondary palate fusion.Nature genetics · 1995Article
- Face facts: genes, environment, and clefts.American journal of human genetics · 1995Article
- Case-parental control method in the search for disease-susceptibility genes.American journal of human genetics · 1994Article
- Transforming growth factor alpha polymorphism and cleft lip and palate in North Indian Population.National journal of maxillofacial surgeryArticle
- Association of Transforming Growth Factor Alpha Polymorphisms with Nonsyndromic Cleft Lip and Palate in Iranian Population.Avicenna journal of medical biotechnologyArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Genetic analysis and tissue-specific expression studies support a role for transforming growth-factor alpha (TGFA) in craniofacial development. Previous studies have confirmed an association of alleles for TGFA with nonsyndromic cleft lip with or without cleft palate (CL/P) in humans. We carried out a retrospective association study to determine whether specific allelic variants of the TGFA gene are also associated with cleft palate only (CPO). The PCR products from 12 overlapping sets of primers to the TGFA cDNA were examined by using single-strand conformational polymorphism analysis. Four DNA polymorphic sites for TGFA were identified in the 3' untranslated region of the TGFA gene. These variants, as well as previously identified RFLPs for TGFA, were characterized in case and control populations for CPO by using chi 2 analysis. A significant association between alleles of TGFA and CPO was identified which further supports a role for this gene as one of the genetic determinants of craniofacial development. Sequence analysis of the variants disclosed a cluster of three variable sites within 30 bp of each other in the 3' untranslated region previously associated with an antisense transcript. These studies extend the role for TGFA in craniofacial morphogenesis and support an interrelated mechanism underlying nonsyndromic forms of CL/P.
Indexed as
Identifiers
8105683PMC1682388W106713413What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.