ArticleProceedings of the National Academy of Sciences of the United States of America1993
Crosstalk between alpha/beta T cells and gamma/delta T cells in vivo: activation of alpha/beta T-cell responses after gamma/delta T-cell modulation with the monoclonal antibody GL3.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 113 citations in OpenAlex.
- γδ T cells in diabetes mellitus: dual roles and therapeutic implications.Frontiers in immunology · 2025Review
- Inhibition of γδ-TcR or IL17a Reduces T-Cell and Neutrophil Infiltration after Ischemia/Reperfusion Injury in Mouse Liver.Journal of clinical medicine · 2023Article
- B Cell and CD4 T Cell Interactions Promote Development of Atherosclerosis.Frontiers in immunology · 2019Article
- Genetic models reveal origin, persistence and non-redundant functions of IL-17-producing γδ T cells.The Journal of experimental medicine · 2018Article
- γδT cells regulate chronic airway inflammation and development of airway remodelling.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2014Article
- γδ T cell and other immune cells crosstalk in cellular immunity.Journal of immunology research · 2014Review
- CD4 T cells play important roles in maintaining IL-17-producing γδ T-cell subsets in naive animals.Immunology and cell biology · 2012Article
- Regulatory effect of gammadelta T cells on IL-17+ uveitogenic T cells.Investigative ophthalmology & visual science · 2010Article
- Human peripheral gammadelta T cells possess regulatory potential.Immunology · 2009Article
- Major role of gamma delta T cells in the generation of IL-17+ uveitogenic T cells.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Article
- {gamma}{delta} T cell homeostasis is established in competition with {alpha}{beta} T cells and NK cells.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Innate immune surveillance of spontaneous B cell lymphomas by natural killer cells and gammadelta T cells.The Journal of experimental medicine · 2004Article
- Responses of bovine WC1(+) gammadelta T cells to protein and nonprotein antigens of Mycobacterium bovis.Infection and immunity · 2002Article
- Increased host resistance against Pneumocystis carinii pneumonia in gammadelta T-cell-deficient mice: protective role of gamma interferon and CD8(+) T cells.Infection and immunity · 2002Article
- Exaggerated proinflammatory and Th1 responses in the absence of gamma/delta T cells after infection with Listeria monocytogenes.Infection and immunity · 2001Article
- A critical role for interleukin 18 in primary and memory effector responses to Listeria monocytogenes that extends beyond its effects on Interferon gamma production.The Journal of experimental medicine · 2001Article
- Characterization of the porcine gammadelta T-cell receptor structure and cellular distribution by monoclonal antibody PPT27.Immunology · 2000Article
- Identification of distinct lymphocyte subsets responding to subcellular fractions of Mycobacterium bovis bacille calmette-Guérin (BCG).Clinical and experimental immunology · 2000Article
- Antigen-recognition properties of murine gamma delta T cells.Springer seminars in immunopathology · 2000Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although gamma/delta T cells express numerous in vitro functions similar to alpha/beta T cells, little is known about their biological functioning in vivo. Furthermore, it is unclear whether alpha/beta T cells and gamma/delta T cells act independently or in a coordinated way. In the present study, gamma/delta T cells were modulated in vivo by i.p. injection of the anti-gamma/delta T-cell receptor (TCR) monoclonal antibody GL3. GL3 administration caused disappearance of the gamma/delta TCR in spleen and lymph node cells and the gamma/delta TCR was reexpressed after in vitro cultivation for a few days. When cultured in vitro for 4 days, in the absence of foreign antigens, spleen and lymph node alpha/beta T cells from GL3-modulated mice showed vigorous proliferative responses. CD4 T lymphocytes from GL3-modulated mice produced interleukin 2, and CD8 T cells developed into cytolytic T lymphocytes in vitro capable of lysing syngeneic and allogeneic targets. Treatment with heat-inactivated GL3 or with normal hamster immunoglobulin did not cause any of these effects. These findings suggest that the anti-gamma/delta TCR monoclonal antibody GL3 modulates gamma/delta T cells in vivo and that this modulation has profound effects on alpha/beta T-cell reactivity. Hence, the data suggest a role for gamma/delta T cells in the regulation of alpha/beta T-cell activation in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.