ArticleProceedings of the National Academy of Sciences of the United States of America1993
Genetic mapping of tumor susceptibility genes involved in mouse plasmacytomagenesis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 90 citations in OpenAlex.
- Conditional deletion of mTOR discloses its essential role in early B-cell development.Molecular carcinogenesis · 2022Article
- Distinct Tumor Microenvironments Are a Defining Feature of Strain-Specific CRISPR/Cas9-Induced MPNSTs.Genes · 2020Article
- Mouse tumor susceptibility genes identify drug combinations for multiple myeloma.Journal of cancer metastasis and treatment · 2020Article
- The transcription factor MZF1 differentially regulates murineThe Journal of biological chemistry · 2019Article
- Plasmacytomagenesis in Eμ-v-abl transgenic mice is accelerated when apoptosis is restrained.Blood · 2014Article
- Scram1 is a modifier of spinal cord resistance for astrocytoma on mouse Chr 5.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Article
- Loci controlling lymphocyte production of interferon c after alloantigen stimulation in vitro and their co-localization with genes controlling lymphocyte infiltration of tumors and tumor susceptibility.Cancer immunology, immunotherapy : CII · 2010Article
- Article
- QTL analyses of lineage-negative mouse bone marrow cells labeled with Sca-1 and c-Kit.Mammalian genome : official journal of the International Mammalian Genome Society · 2008Article
- Frap, FKBP12 rapamycin-associated protein, is a candidate gene for the plasmacytoma resistance locus Pctr2 and can act as a tumor suppressor gene.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- p16 INK4a gene promoter variation and differential binding of a repressor, the ras-responsive zinc-finger transcription factor, RREB.Oncogene · 2003Article
- Multiple genetic loci modify susceptibility to plasmacytoma-related morbidity in E(mu)-v-abl transgenic mice.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Failure of ureteric bud invasion: a new model of renal agenesis in mice.The American journal of pathology · 2001Article
- Five quantitative trait loci affecting 4-nitroquinoline 1-oxide-induced tongue cancer in the rat.Japanese journal of cancer research : Gann · 2001Article
- Efficiency alleles of the Pctr1 modifier locus for plasmacytoma susceptibility.Molecular and cellular biology · 2001Article
- Cdkn2a, the cyclin-dependent kinase inhibitor encoding p16INK4a and p19ARF, is a candidate for the plasmacytoma susceptibility locus, Pctr1.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Role of interleukin-6 in the pathogenesis of murine plasmacytoma and human multiple myeloma.The American journal of pathology · 1997Article
- Mouse mammary tumor virus/v-Ha-ras transgene-induced mammary tumors exhibit strain-specific allelic loss on mouse chromosome 4.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Genetic controls of susceptibility and resistance to 4-nitroquinoline 1-oxide-induced tongue carcinomas in rats.Japanese journal of cancer research : Gann · 1996Article
- Riz maps to distal chromosome 4 near genes involved in tumorigenesis and nerve degeneration.Mammalian genome : official journal of the International Mammalian Genome Society · 1996Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Plasmacytomas (PCTs) were induced in 47% of BALB/cAnPt mice by the intraperitoneal injection of pristane, in 2% of (BALB/c x DBA/2N)F1, and in 11% of 773 BALB/cAnPt x (BALB/cAnPt x DBA/2N)F1 N2 backcross mice. This result indicates a multigenic mode of inheritance for PCT susceptibility. To locate genes controlling this complex genetic trait, tumor susceptibility in backcross progeny generated from BALB/c and DBA/2N (resistant) mice was correlated with alleles of 83 marker loci. The genotypes of the PCT-susceptible progeny displayed an excess homozygosity for BALB/c alleles within a 32-centimorgan stretch of mouse chromosome 4 (> 95% probability of linkage) with minimal recombination (12%) near Gt10. Another susceptibility gene on mouse chromosome 1 may be linked to Fcgr2 (90% probability of linkage); there were excess heterozygotes for Fcgr2 among the susceptible progeny and excess homozygotes among the resistant progeny. Regions of mouse chromosomes 4 and 1 that are correlated with PCT susceptibility share extensive linkage homology with regions of human chromosome 1 that have been associated with cytogenetic abnormalities in multiple myeloma and lymphoid, breast, and endocrine tumors.
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