ArticleProceedings of the National Academy of Sciences of the United States of America1993
Residual free calcium is not responsible for facilitation of neurotransmitter release.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 53 citations in OpenAlex.
- Synaptotagmin CaFrontiers in molecular neuroscience · 2018Review
- A use-dependent increase in release sites drives facilitation at calretinin-deficient cerebellar parallel-fiber synapses.Frontiers in cellular neuroscience · 2015Article
- New insights into short-term synaptic facilitation at the frog neuromuscular junction.Journal of neurophysiology · 2015Article
- Paired-pulse facilitation at recurrent Purkinje neuron synapses is independent of calbindin and parvalbumin during high-frequency activation.The Journal of physiology · 2013Article
- Pathway-specific use-dependent dynamics of excitatory synaptic transmission in rat intracortical circuits.The Journal of physiology · 2007Article
- Influences of different developmental periods of taurine supplements on synaptic plasticity in hippocampal CA1 area of rats following prenatal and perinatal lead exposure.BMC developmental biology · 2007Article
- The facilitated probability of quantal secretion within an array of calcium channels of an active zone at the amphibian neuromuscular junction.Biophysical journal · 2004Article
- Modulation of spike-mediated synaptic transmission by presynaptic background Ca2+ in leech heart interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Effects of mobile buffers on facilitation: experimental and computational studies.Biophysical journal · 2000Article
- Differential roles of Ca2+/calmodulin-dependent kinases in posttetanic potentiation at input selective glutamatergic pathways.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Calcium-dependent regulation of rab3 in short-term plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Calcium currents, transmitter release and facilitation of release at voltage-clamped crayfish nerve terminals.The Journal of physiology · 1996Article
- Determinants of the time course of facilitation at the granule cell to Purkinje cell synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1996Article
- Lambert-Eaton sera reduce low-voltage and high-voltage activated Ca2+ currents in murine dorsal root ganglion neurons.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Calcium in the nerve terminals of chick ciliary ganglia during facilitation, augmentation and potentiation.The Journal of physiology · 1995Article
- Calcium transients in cerebellar granule cell presynaptic terminals.Biophysical journal · 1995Article
- Stochastic modeling of facilitated neurosecretion.Journal of computational neuroscienceArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An increase in internal free calcium ([Ca2+]i) in the presynaptic terminal is often assumed to directly produce facilitation of neurotransmitter release. Using a Ca(2+)-activated potassium conductance as a bioassay for free [Ca2+]i in the presynaptic terminal of the crayfish (Procambarus clarkii) opener neuromuscular junction, we now demonstrate that free [Ca2+]i has a decay time constant (tau) of 1-4 msec, whereas facilitation of neurotransmitter release has a decay tau of 7-43 msec. In addition, facilitation of neurotransmitter release can be markedly different at times when free [Ca2+]i values and presynaptic membrane voltages are equal. We conclude that free [Ca2+]i in the presynaptic terminal is not directly responsible for facilitation of neurotransmitter release. Our data suggest that facilitation results from bound Ca2+ or some long-lived consequence of bound Ca2+.
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