ArticleJournal of cancer research and clinical oncology1993
Comparative analysis of p53 and c-myc expression and cell proliferation in human hepatocellular carcinomas--an enhanced immunohistochemical approach.
Article in Journal of cancer research and clinical oncology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 23 citations in OpenAlex.
- Downregulation of GMPS inhibited the proliferation of hepatocellular cancer cellsEuropean journal of histochemistry : EJH · 2026Article
- The Clinicopathologic and Prognostic Significance of c-Myc Expression in Hepatocellular Carcinoma: A Meta-Analysis.Frontiers in bioinformatics · 2021Review
- Hepatitis C virus-induced activation of β-catenin promotes c-Myc expression and a cascade of pro-carcinogenetic events.Oncogene · 2013Article
- Molecular Signatures of Recurrent Hepatocellular Carcinoma Secondary to Hepatitis C Virus following Liver Transplantation.Journal of transplantation · 2013Article
- Is p53 gene mutation an indicatior of the biological behaviors of recurrence of hepatocellular carcinoma?World journal of gastroenterology · 2003Article
- The significance of p53 mutations as an indicator of the biological behavior of recurrent hepatocellular carcinomas.Surgery today · 1999Article
- In situ characterization of inflammatory responses in the rectal mucosae of patients with shigellosis.Infection and immunity · 1997Article
- Classification of hepatocellular carcinoma according to hepatocellular and biliary differentiation markers. Clinical and biological implications.The American journal of pathology · 1996Article
- p53 expression in normal and dysplastic bronchial epithelium and in lung carcinomas.British journal of cancer · 1994Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Expression of p53 and c-myc was investigated and compared with cell proliferative activity in a series of 40 hepatocellular carcinomas (HCC), by means of enhanced immunohistochemistry. p53 expression was demonstrated in 5 out of 40 HCC (12.5%) with the incidence increasing in 5 out of 40 HCC (12.5%) with the incidence increasing in proportion to the histological grading of malignancy: thus, 0% of well-differentiated, 6.9% of moderately differentiated and 33.3% of poorly differentiated lesions were positive. The proliferating-cell nuclear antigen (PCNA) labeling index also showed a statistically significant increase with this grading. Distribution patterns of PCNA-positive cell were divided into four types: scatter, marginal, mosaic and diffuse. Four HCC cases, predominantly of the poorly differentiated type, exhibited the diffuse pattern. Generally, p53 overexpression corresponded well with PCNA positivity. In contrast, there was no correlation between c-myc overexpression, found in 19 out of 40 HCC (47.5%), and histological grading of HCC or PCNA labeling index. The distribution pattern of c-myc-positive HCC cells was also different from that of PCNA and p53. Our results suggest that p53 overexpression closely relates to proliferation of HCC cells. Furthermore, there may be a consistent difference in regulatory mechanisms between p53 and c-myc expression in multistep hepatocarcinogenesis.
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