ArticleProceedings of the National Academy of Sciences of the United States of America1993
Single intraluminal delivery of antisense cdc2 kinase and proliferating-cell nuclear antigen oligonucleotides results in chronic inhibition of neointimal hyperplasia.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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Who cites it
71 citing papers in PubMed, 457 citations in OpenAlex.
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- Nanoparticle drug- and gene-eluting stents for the prevention and treatment of coronary restenosis.Theranostics · 2014Review
- Efficacy of cilostazol on uncontrolled coronary vasospastic angina: a pilot study.Cardiovascular therapeutics · 2013Article
- Preventing intimal thickening of vein grafts in vein artery bypass using STAT-3 siRNA.Journal of translational medicine · 2012Article
- Nitric oxide-dependent bone marrow progenitor mobilization by carbon monoxide enhances endothelial repair after vascular injury.Circulation · 2010Article
- Augmented cell cycle protein expression and kinase activity in atherosclerotic rabbit vessels.Experimental and clinical cardiology · 2010Article
- Coronary vein graft disease: pathogenesis and prevention.The Canadian journal of cardiology · 2009Review
- Nucleic acid drugs for prevention of cardiac rejection.Journal of biomedicine & biotechnology · 2009Review
- Potential role of CYLD (Cylindromatosis) as a deubiquitinating enzyme in vascular cells.The American journal of pathology · 2008Article
- Delivery of large biopharmaceuticals from cardiovascular stents: a review.Biomacromolecules · 2007Review
- Transcription factor decoy oligonucleotide-based therapeutic strategy for renal disease.Clinical and experimental nephrology · 2007Review
- Cardiovascular gene delivery: The good road is awaiting.Advanced drug delivery reviews · 2006Review
- The cell cycle: a critical therapeutic target to prevent vascular proliferative disease.The Canadian journal of cardiology · 2006Review
- Inhibition of PCNA antisense oligonucleotides mediated by liposome on mRNA expression and proliferation of h-RPE cells.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2006Article
- Novel therapeutic approaches for progressive renal disorders by targeting glomerular component mesangial and endothelial cells.Clinical and experimental nephrology · 2005Review
- Nonviral gene transfer to skeletal, smooth, and cardiac muscle in living animals.American journal of physiology. Cell physiology · 2005Review
- Strategy for Prevention of Restenosis after PTA. Clinical and Basic Approaches.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2004Article
- Regulation of vascular smooth muscle cell growth: targeting the final common pathway.Arteriosclerosis, thrombosis, and vascular biology · 2003Article
- Novel E2F decoy oligodeoxynucleotides inhibit in vitro vascular smooth muscle cell proliferation and in vivo neointimal hyperplasia.Gene therapy · 2002Article
11 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To develop an effective strategy to prevent neointima formation after angioplasty injury, we have identified cell-cycle regulatory proteins as targets for inhibition by using antisense oligonucleotides (ODNs). We utilized an intraluminal molecular delivery method that employs the protein coat of a Sendai virus complexed with liposomes that enhances markedly the efficiency of ODNs uptake. First, we examined the effect of antisense cdc2 kinase and proliferating-cell nuclear antigen (PCNA) ODNs in vitro. Cotransfection of antisense cdc2 kinase and PCNA ODNs inhibited serum-stimulated vascular smooth muscle cell growth, whereas antisense cdc2 kinase ODNs alone or PCNA ODNs alone failed to show any inhibitory effect. Transfection of the combination of antisense cdc2 kinase and PCNA ODNs into balloon-injured arteries in vivo provided a marked decrease in cdc2 and PCNA mRNA expression as determined by reverse transcription-PCR, compared to sense controls. Antisense ODN treatment significantly inhibited the increase in DNA synthesis induced by balloon injury. Moreover, antisense ODN administration inhibited completely neointima formation at 2 weeks after angioplasty in an apparent dose-dependent manner. Moreover, the inhibitory effect of antisense ODN on neointima formation persisted up to 8 weeks after a single transfection. The present study documents that a single intraluminal molecular delivery of combined cdc2 kinase and PCNA antisense ODNs results in a sustained inhibition of neointima formation in the rat carotid balloon-injury model.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.