ArticleGenetics1993
Physical mapping of meiotic crossover events in a 200-kb region of Neurospora crassa linkage group I.
Article in Genetics, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Meiosis through three centuries.Chromosoma · 2024Review
- Chromosome walking to the AVR1-CO39 avirulence gene of Magnaporthe grisea: discrepancy between the physical and genetic maps.Genetics · 1998Article
- Article
- Gene conversion alone accounts for more than 90% of recombination events at the am locus of Neurospora crassa.Genetics · 1996Article
- Article
- The orientation of gene maps by recombination of flanking markers for the am locus of Neurospora crassa.Current genetics · 1995Article
- Correlation of the physical and genetic maps of the centromeric region of the right arm of linkage group III of Neurospora crassa.Genetics · 1994Article
- Homologous recombination in fission yeast: absence of crossover interference and synaptonemal complex.Experientia · 1994Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We propose a general restriction fragment length polymorphism-based strategy to analyze the distribution of meiotic crossover events throughout specific genetic intervals. We have isolated 64 recombinant chromosomes carrying independent meiotic crossover events in the genetic interval eth-1-un-2 on linkage group I of Neurospora crassa. Thirty-eight crossover events were physically mapped with reference to a 200-kb region cloned by chromosome walking, using N. crassa lambda and cosmid libraries. Crossovers were homogeneously distributed at intervals of 5.0 +/- 2.3 kb along the entire cloned interval. The ratio of physical to genetic distance appears to be higher in the region than in the overall N. crassa genome, suggesting that recombinational activity is less in large chromosomes than in small ones. The present work provides a method for defining the centromeric-telomeric orientation of single cloned DNA fragments. Their physical distance can also be estimated with respect to linked loci, provided that crossover events are distributed homogeneously in the interval. This strategy overcomes typical difficulties in defining the position and direction of chromosome walking steps on conventional linkage maps.
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