ArticleProceedings of the National Academy of Sciences of the United States of America1993
Susceptibility to renal carcinoma in the Eker rat involves a tumor suppressor gene on chromosome 10.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 66 citations in OpenAlex.
- Choosing The Right Animal Model for Renal Cancer Research.Translational oncology · 2020Review
- Nox4 is a Target for Tuberin Deficiency Syndrome.Scientific reports · 2018Article
- ERK crosstalks with 4EBP1 to activate cyclin D1 translation during quinol-thioether-induced tuberous sclerosis renal cell carcinoma.Toxicological sciences : an official journal of the Society of Toxicology · 2011Article
- Zebrafish Tsc1 reveals functional interactions between the cilium and the TOR pathway.Human molecular genetics · 2009Article
- Nailing down a link between tuberin and renal cysts.The American journal of pathology · 2003Review
- Polycystic kidney disease as a result of loss of the tuberous sclerosis 2 tumor suppressor gene during development.The American journal of pathology · 2003Article
- Renal carcinogenesis: genotype, phenotype and dramatype.Cancer science · 2003Review
- A novel gene "Niban" upregulated in renal carcinogenesis: cloning by the cDNA-amplified fragment length polymorphism approach.Japanese journal of cancer research : Gann · 2000Article
- Genetic mapping of a naturally occurring hereditary renal cancer syndrome in dogs.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Identification of a leader exon and a core promoter for the rat tuberous sclerosis 2 (Tsc2) gene and structural comparison with the human homolog.Mammalian genome : official journal of the International Mammalian Genome Society · 1997Article
- Suppression of tumorigenicity by the wild-type tuberous sclerosis 2 (Tsc2) gene and its C-terminal region.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- A genetic, physical, and comparative map of rat chromosome 10.Mammalian genome : official journal of the International Mammalian Genome Society · 1996Article
- Chromosomal mapping of the rat Slc4a family of anion exchanger genes, Ae1, Ae2, and Ae3.Mammalian genome : official journal of the International Mammalian Genome Society · 1996Article
- The Vpreb1 and comt genes are closely linked and sublocalized to rat chromosome 11q23.Mammalian genome : official journal of the International Mammalian Genome Society · 1996Article
- Cloning of the rat homologue of the von Hippel-Lindau tumor suppressor gene and its non-somatic mutation in rat renal cell carcinomas.Japanese journal of cancer research : Gann · 1995Article
- Allelic loss at the tuberous sclerosis (Tsc2) gene locus in spontaneous uterine leiomyosarcomas and pituitary adenomas in the Eker rat model.Japanese journal of cancer research : Gann · 1995Article
- cDNA structure, alternative splicing and exon-intron organization of the predisposing tuberous sclerosis (Tsc2) gene of the Eker rat model.Nucleic acids research · 1995Article
- [Model systems for investigation of genetic factors in tumorigenesis].Die Naturwissenschaften · 1995Review
- Isolation of microdissection clones from rat chromosome 10.Mammalian genome : official journal of the International Mammalian Genome Society · 1995Article
- Renal carcinogenesis in the Eker rat.Journal of cancer research and clinical oncology · 1995Article
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4 authors at 1 institution in 1 country.
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Abstract
Germ-line mutations of tumor suppressor genes confer strong predisposition to tumor formation. In the rat, a form of dominantly inherited renal carcinoma (RC) results in multiple chromophobe cell tumors that resemble the human disease, and heterozygous carriers (RC/+) are highly susceptible to environmental agents (radiation and chemical carcinogens), making it a desirable model to study epithelial carcinogenesis. By linkage analysis, the locus of the inherited RC mutation was mapped to rat chromosomal band 10q12, near the protamine locus (logarithm of odds score = 17.96). Renal tumors also showed a loss of heterozygosity at this locus, lending support to the recessive nature of this putative tumor suppressor gene. Our result suggested that the human homolog of the RC gene may reside on human chromosome 16, not known to be altered commonly in human RC.
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