ArticleArchives of virology1993
Genomic characterization of two predominant genotypes of herpes simplex virus type 1.
Article in Archives of virology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Article
- Evolution and diversity in human herpes simplex virus genomes.Journal of virology · 2014Article
- Analysis of enzymatic digestion pattern of two open reading frames of Varciella-Zoster genome from Kuwaiti patients using the RFLP technique.Iranian journal of microbiology · 2012Article
- Complete-genome phylogenetic approach to varicella-zoster virus evolution: genetic divergence and evidence for recombination.Journal of virology · 2006Article
- Global identification of three major genotypes of varicella-zoster virus: longitudinal clustering and strategies for genotyping.Journal of virology · 2004Article
- Phylogenetic analysis of varicella-zoster virus: evidence of intercontinental spread of genotypes and recombination.Journal of virology · 2002Article
- Cleavage in and around the DR1 element of the A sequence of herpes simplex virus type 1 relevant to the excision of DNA fragments with length corresponding to one and two units of the A sequence.Journal of virology · 2001Article
- Comparison of polymorphism of thymidine kinase gene and restriction fragment length polymorphism of genomic DNA in herpes simplex virus type 1.Journal of clinical microbiology · 2000Article
- Amplification of reiterated sequences of herpes simplex virus type 1 (HSV-1) genome to discriminate between clinical HSV-1 isolates.Journal of clinical microbiology · 1999Article
- Numerous length polymorphisms at short tandem repeats in human cytomegalovirus.Journal of virology · 1999Article
- Inhibition of generation of authentic genomic termini of herpes simplex virus type 1 DNA in temperature-sensitive mutant BHK-21 cells with a mutated CCG1/TAF(II)250 gene.Journal of virology · 1996Article
- Excision of DNA fragments corresponding to the unit-length a sequence of herpes simplex virus type 1 and terminus variation predominate on one side of the excised fragment.Journal of virology · 1994Article
- Preparation of herpes simplex virus type 1 genomic markers to differentiate strains of predominant genotypes.Archives of virology · 1994Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genomic profiles of 66 strains of herpes simplex virus type 1 (HSV-1) isolated in Japan were investigated with regard to restriction fragment length polymorphism (RFLP) and length variation of fragments containing reiterations. There were two predominant genotypes of F1 and F35, and the genomic characteristics of each were studied. The nucleotide change between F1 and F35 was estimated to be 1.5%. An RFLP marker (VR23) peculiar to genotype F35 was identified as the first case of genomic marker specific to a predominant genotype of HSV-1, and is the diagnostic marker of F35. The a sequences (repeating in an HSV-1 genome and containing reiterations) of F35 were cleaved by SacII on the DR4 (direct repeat 4) stretch, while a sequences of F1 had a rearranged DR4 and were resistant to SacII digestion. Thus, analyses of fragments containing reiterations, such as a sequences, can serve to classify HSV-1 strains as well as for purpose of differentiation. The proportion of strains derived from primary infection to those from recurrent infection was higher in strains of F35 than in those of F1, and this genotypic difference within HSV-1 may possibly influence clinical manifestations.
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