ArticleJournal of cancer research and clinical oncology1993
Prognostic significance of the expression of c-fos, c-jun and c-erbB-1 oncogene products in human squamous cell lung carcinomas.
Article in Journal of cancer research and clinical oncology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Pooled it
- The role of HER-2/neu expression on the survival of patients with lung cancer: a systematic review of the literature.British journal of cancer · 2003Pooled it
- SHC1 Promotes Lung Cancer Metastasis by Interacting with EGFR.Journal of oncology · 2022Article
- Immune checkpoint inhibitors for PD-1/PD-L1 axis in combination with other immunotherapies and targeted therapies for non-small cell lung cancer.Frontiers in oncology · 2022Review
- An Aging-Related Gene Signature-Based Model for Risk Stratification and Prognosis Prediction in Lung Squamous Carcinoma.Frontiers in cell and developmental biology · 2022Article
- Strategies for Improving Photodynamic Therapy Through Pharmacological Modulation of the Immediate Early Stress Response.Methods in molecular biology (Clifton, N.J.) · 2022Review
- Identification of Survival-Associated Alternative Splicing Signatures in Lung Squamous Cell Carcinoma.Frontiers in oncology · 2020Article
- Tumor suppressive role of miR-569 in lung cancer.Oncology letters · 2018Article
- Cigarette Smoke Mediates Nuclear to Cytoplasmic Trafficking of Transcriptional Inhibitor Kaiso through MUC1 and P120-Catenin.The American journal of pathology · 2016Article
- c-Fos over-expression promotes radioresistance and predicts poor prognosis in malignant glioma.Oncotarget · 2016Article
- Fra-1 is a key driver of colon cancer metastasis and a Fra-1 classifier predicts disease-free survival.Oncotarget · 2015Article
- Prostaglandin E2 stimulates normal bronchial epithelial cell growth through induction of c-Jun and PDK1, a kinase implicated in oncogenesis.Respiratory research · 2015Article
- Cell membrane CD44v6 levels in squamous cell carcinoma of the lung: association with high cellular proliferation and high concentrations of EGFR and CD44v5.International journal of molecular sciences · 2015Article
- Expression of c-fos was associated with clinicopathologic characteristics and prognosis in pancreatic cancer.PloS one · 2015Article
- Concurrent MCL1 and JUN amplification in pseudomyxoma peritonei: a comprehensive genetic profiling and survival analysis.Journal of human genetics · 2014Article
- Knockdown of c-Fos suppresses the growth of human colon carcinoma cells in athymic mice.International journal of cancer · 2012Article
- Prognostic value of epidermal growth factor receptor expression in operable non-small cell lung carcinoma.Multidisciplinary respiratory medicine · 2010Article
- A dominant-negative c-jun mutant inhibits lung carcinogenesis in mice.Cancer prevention research (Philadelphia, Pa.) · 2010Article
- Coexpression of epidermal growth factor receptor with related factors is associated with a poor prognosis in non-small-cell lung cancer.British journal of cancer · 2004Article
- Epidermal growth factor receptor (EGFR) expression in operable non-small cell lung carcinoma.Journal of Korean medical science · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The expression of the oncogenes c-fos, c-jun, c-myc, c-erbB-1 and c-erbB-2 at the protein level was analyzed in squamous cell lung carcinomas of 121 patients by means of immunohistochemistry. Patients with overexpression of proteins encoded by the oncogenes c-fos, c-jun and c-erbB-1 had significantly shorter survival times than these without overexpression of these oncogene products (c-fos: p = 0.009; c-jun: p = 0.029; c-erbB-1: p = 0.018). No significant correlations were found between the expression of c-myc and c-erbB-2 products and the survival of the patients. In addition to the univariate analyses (Kaplan-Meier-estimates) multivariate analyses (Cox-regression-model) revealed that protein expression of the oncogenes c-fos, c-jun and c-erbB-1 are significant prognostic factors in addition to staging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.