ArticleAnnals of surgery1993
Elemental diet-induced bacterial translocation can be hormonally modulated.
Article in Annals of surgery, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 44 citations in OpenAlex.
- Review
- Nutrition of the critically ill - emphasis on liver and pancreas.Hepatobiliary surgery and nutrition · 2012Review
- Review
- Small amount of low-residue diet with parenteral nutrition can prevent decreases in intestinal mucosal integrity.Annals of surgery · 2000Article
- Route and type of nutrition influence IgA-mediating intestinal cytokines.Annals of surgery · 1999Article
- Route and type of nutrition influence mucosal immunity to bacterial pneumonia.Annals of surgery · 1999Article
- Loss of upper respiratory tract immunity with parenteral feeding.Annals of surgery · 1996Article
- Elemental diet and IV-TPN-induced bacterial translocation is associated with loss of intestinal mucosal barrier function against bacteria.Annals of surgery · 1995Article
- Secretory immunoglobulin A, intestinal mucin, and mucosal permeability in nutritionally induced bacterial translocation in rats.Annals of surgery · 1994Article
- Bombesin improves survival from methotrexate-induced enterocolitis.Annals of surgery · 1994Article
- Fiber: effect on bacterial translocation and intestinal mucin content.World journal of surgeryArticle
- Inducible nitric oxide synthase knockout mice are resistant to diet-induced loss of gut barrier function and intestinal injury.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary TractArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe authors have previously documented that feeding mice an elemental diet resulted in bacterial translocation (BT) that could be prevented by the provision of dietary fiber. To test whether the protective effect of fiber was related to the stimulation of trophic gut hormones, the effects of sandostatin and bombesin were tested.
methodsMice fed either chow or the elemental diet were stratified into several groups and the ability of bombesin (10 micrograms/kg, tid) or sandostatin (100 micrograms/kg bid) to modulate BT was examined. After 14 days, mice were sacrificed and BT, cecal bacterial population levels, mucosal protein, and small bowel weight was measured. Segments of the ileum and jejunum were examined histologically.
resultsIncidence of elemental diet-induced BT (75%) was reduced by fiber (9%) or the administration of bombesin (13%) (p < 0.01). Although sandostatin did not promote BT in chow-fed mice, it reversed the protective effect of fiber on BT (75%) (p < 0.01).
conclusionElemental diet-induced bacterial translocation can be modulated hormonally and the beneficial effects of fiber on diet-induced BT appears to be hormonally mediated.
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Registered trials
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