ArticleProceedings of the National Academy of Sciences of the United States of America1993
Identification and cloning of a protein kinase-encoding mouse gene, Plk, related to the polo gene of Drosophila.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 160 citations in OpenAlex.
- Design, synthesis, and biological evaluation of indazole-based PLK4 inhibitors.RSC medicinal chemistry · 2025Article
- Polo-like Kinase 1 Inhibitors Demonstrate In Vitro and In Vivo Efficacy in Preclinical Models of Small Cell Lung Cancer.Cancers · 2025Article
- Leveraging the Fragment Molecular Orbital Method to Explore the PLK1 Kinase Binding Site and Polo-Box Domain for Potent Small-Molecule Drug Design.International journal of molecular sciences · 2023Article
- The Role of Polo-Like Kinase 1 in Regulating the Forkhead Box Family Transcription Factors.Cells · 2023Review
- BUB1 and CENP-U, Primed by CDK1, Are the Main PLK1 Kinetochore Receptors in Mitosis.Molecular cell · 2021Article
- MCC1019, a selective inhibitor of the Polo-box domain of Polo-like kinase 1 as novel, potent anticancer candidate.Acta pharmaceutica Sinica. B · 2019Article
- Regulation of PLK1 through competition between hnRNPK, miR-149-3p and miR-193b-5p.Cell death and differentiation · 2017Article
- Volasertib for AML: clinical use and patient consideration.OncoTargets and therapy · 2015Review
- A 3'UTR polymorphism modulates mRNA stability of the oncogene and drug target Polo-like Kinase 1.Molecular cancer · 2014Article
- Mechanisms underlying Plk1 polo-box domain-mediated biological processes and their physiological significance.Molecules and cells · 2014Review
- Polo-like kinase 2, a novel ADAM17 signaling component, regulates tumor necrosis factor α ectodomain shedding.The Journal of biological chemistry · 2014Article
- The role of polo-like kinase 1 in carcinogenesis: cause or consequence?Cancer research · 2013Review
- Polo-like kinase 1, on the rise from cell cycle regulation to prostate cancer development.Protein & cell · 2012Review
- Calcium-dependent inhibition of polo-like kinase 3 activity by CIB1 in breast cancer cells.International journal of cancer · 2011Article
- RNA interference against polo-like kinase-1 in advanced non-small cell lung cancers.Journal of clinical bioinformatics · 2011Article
- Calcium- and integrin-binding protein 1 regulates microtubule organization and centrosome segregation through polo like kinase 3 during cell cycle progression.The international journal of biochemistry & cell biology · 2011Article
- Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy.Nature reviews. Drug discovery · 2010Review
- Polo-box domain: a versatile mediator of polo-like kinase function.Cellular and molecular life sciences : CMLS · 2010Review
- Phosphorylation of synucleins by members of the Polo-like kinase family.The Journal of biological chemistry · 2010Article
- Stimulation of polo-like kinase 3 mRNA decay by tristetraprolin.Molecular and cellular biology · 2009Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have determined the nucleotide sequence of a cDNA encoding a protein kinase that is closely related to the enzyme encoded by the Drosophila melanogaster mutant polo and that we have designated Plk (polo-like kinase). Plk is also related to the products of the Saccharomyces cerevisiae cell cycle gene MSD2 (CDC5) and the recently described early growth response gene Snk. Together, Plk, polo, Snk, and MSD2 define a subfamily of serine/threonine protein kinases. Plk is expressed at high levels in a number of fetal and newborn mouse tissues but is not expressed in the corresponding adult organs. With the exception of adult hemopoietic tissues, the only adult tissues in which we could detect Plk expression were ovaries and testes. Taken together, the patterns of Plk expression suggest an association with proliferating cells. Since polo is required for mitosis in Drosophila it is possible that Plk is involved in some aspect of cell cycle regulation in mammalian cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.