ArticleProceedings of the National Academy of Sciences of the United States of America1993
The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 128 citations in OpenAlex.
- The effect of TLX3 expression on the prognosis of pediatric T cell acute lymphocytic leukemia--a systematic review.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- TLX3 regulates CGN progenitor proliferation during cerebellum development and its dysfunction can lead to autism.iScience · 2024Article
- Tlx1 regulates acinar and duct development in mouse salivary glands.Journal of anatomy · 2024Article
- A novel mouse model of intestinal neuronal dysplasia: visualization of the enteric nervous system.Pediatric surgery international · 2023Article
- Long Non-coding RNA HOXA11-AS Facilitates Proliferation of Lung Adenocarcinoma CellsFrontiers in genetics · 2022Article
- Identification of key genes involved in the recurrence of glioblastoma multiforme using weighted gene co-expression network analysis and differential expression analysis.Bioengineered · 2021Article
- The Genetics and Mechanisms of T-Cell Acute Lymphoblastic Leukemia.Cold Spring Harbor perspectives in medicine · 2020Review
- HOXA11 antisense long noncoding RNA (HOXA11-AS): A promising lncRNA in human cancers.Cancer medicine · 2018Review
- The genetics and mechanisms of T cell acute lymphoblastic leukaemia.Nature reviews. Cancer · 2016Review
- The DN2 Myeloid-T (DN2mt) Progenitor is a Target Cell for Leukemic Transformation by the TLX1 Oncogene.Journal of bone marrow research · 2013Article
- The molecular basis of T cell acute lymphoblastic leukemia.The Journal of clinical investigation · 2012Review
- Transient responses to NOTCH and TLX1/HOX11 inhibition in T-cell acute lymphoblastic leukemia/lymphoma.PloS one · 2011Article
- Lentiviral fluorescent protein expression vectors for biotinylation proteomics.Methods in molecular biology (Clifton, N.J.) · 2011Article
- TLX1 and NOTCH coregulate transcription in T cell acute lymphoblastic leukemia cells.Molecular cancer · 2010Article
- Cooperative DNA-binding and sequence-recognition mechanism of aristaless and clawless.The EMBO journal · 2010Article
- Hematopoietic immortalizing function of the NKL-subclass homeobox gene TLX1.Genes, chromosomes & cancer · 2010Article
- Comparative genomics of Lbx loci reveals conservation of identical Lbx ohnologs in bony vertebrates.BMC evolutionary biology · 2008Article
- Review
- TLX1/HOX11-induced hematopoietic differentiation blockade.Oncogene · 2007Article
- Mutations in TCF4, encoding a class I basic helix-loop-helix transcription factor, are responsible for Pitt-Hopkins syndrome, a severe epileptic encephalopathy associated with autonomic dysfunction.American journal of human genetics · 2007Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A translocation involving human chromosome 10, band q24, in a subset of T-cell acute leukemias disrupts a region surrounding the putative oncogene HOX11, which encodes a protein with a homeodomain. The HOX11 protein binds to a specific DNA sequence, it localizes to the cell nucleus, and it transactivates transcription of a reporter gene linked to a cis-regulatory element, suggesting that HOX11 functions in vivo as a positive transcription activator. PCR analysis shows that the HOX11 homeodomain is a member of a distinct class of homeodomains, representatives of which occur in murine and Drosophila genomes. These all contain a threonine residue in place of the more common isoleucine or valine in helix 3 of the homeodomain. HOX11 therefore appears to belong to a family of DNA-binding transactivators of transcription.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.