ArticleProceedings of the National Academy of Sciences of the United States of America1993
A homeobox gene of the Antennapedia class is required for human adult erythropoiesis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 45 citations in OpenAlex.
- Role of HOX Genes in Stem Cell Differentiation and Cancer.Stem cells international · 2018Review
- Review
- Review
- Differential expression of HOX genes upon activation of leukocyte sub-populations.International journal of hematology · 2008Article
- Article
- Thrombopoietin, flt3-ligand and c-kit-ligand modulate HOX gene expression in expanding cord blood CD133 cells.Cell proliferation · 2004Article
- The role of gene duplication in the evolution and function of the vertebrate Dlx/distal-less bigene clusters.Journal of structural and functional genomics · 2003Review
- Induction of the angiogenic phenotype by Hox D3.The Journal of cell biology · 1997Article
- Inhibition of DLX-7 homeobox gene causes decreased expression of GATA-1 and c-myc genes and apoptosis.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia.Molecular and cellular biology · 1997Article
- Cloning and expression of a new HOXC6 transcript encoding a repressing protein.The Biochemical journal · 1996Article
- Coordinate expression and proliferative role of HOXB genes in activated adult T lymphocytes.Molecular and cellular biology · 1994Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this report we investigate the role of homeobox genes of the Antennapedia class in adult erythropoiesis, the process by which erythrocytes are formed in the bone marrow. We initially identified Hox genes expressed in mouse erythroleukemia cells by a PCR technique using degenerate primers capable of detecting most of the known genes in Hox clusters 1-4. Four different transcripts, Hox-3.3, -3.5, -3.6, and -4.3 were identified. An antisense oligonucleotide directed against HOX3C (human homologue of Hox-3.3) was used to study the effect of the colony formation by human erythroid progenitor cells. The oligonucleotide inhibited the formation of colony-forming unit erythroid-derived colonies but did not affect the size or degree of hemoglobinization. The more primitive erythroid burst-forming unit colonies or myeloid colonies were not affected. These results show that Hox-3.3 is involved in an early step in the proliferation of the erythroid colony-forming unit subset of progenitor cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.